We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
RNA tissue category: Group enriched (pancreas, liver, lung, gallbladder)
GENE INFORMATION
Gene name
FOXA2 (HGNC Symbol)
Synonyms
HNF3B
Description
Forkhead box A2 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific genes such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. This gene has been linked to sporadic cases of maturity-onset diabetes of the young. Transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Oct 2008]
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000432 [positive regulation of transcription from RNA polymerase II promoter by glucose] GO:0000433 [negative regulation of transcription from RNA polymerase II promoter by glucose] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0001708 [cell fate specification] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0008134 [transcription factor binding] GO:0008344 [adult locomotory behavior] GO:0009653 [anatomical structure morphogenesis] GO:0010719 [negative regulation of epithelial to mesenchymal transition] GO:0016568 [chromatin modification] GO:0019904 [protein domain specific binding] GO:0030154 [cell differentiation] GO:0030193 [regulation of blood coagulation] GO:0031018 [endocrine pancreas development] GO:0033132 [negative regulation of glucokinase activity] GO:0040019 [positive regulation of embryonic development] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0061178 [regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0070741 [response to interleukin-6] GO:0071542 [dopaminergic neuron differentiation] GO:0090009 [primitive streak formation] GO:2000049 [positive regulation of cell-cell adhesion mediated by cadherin] GO:2000543 [positive regulation of gastrulation] GO:2000971 [negative regulation of detection of glucose]
Predicted intracellular proteins Transcription factors Helix-turn-helix domains Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000432 [positive regulation of transcription from RNA polymerase II promoter by glucose] GO:0000433 [negative regulation of transcription from RNA polymerase II promoter by glucose] GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0001205 [transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0001228 [transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding] GO:0001701 [in utero embryonic development] GO:0001705 [ectoderm formation] GO:0001708 [cell fate specification] GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006357 [regulation of transcription from RNA polymerase II promoter] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007219 [Notch signaling pathway] GO:0007389 [pattern specification process] GO:0008134 [transcription factor binding] GO:0008344 [adult locomotory behavior] GO:0009653 [anatomical structure morphogenesis] GO:0009952 [anterior/posterior pattern specification] GO:0009953 [dorsal/ventral pattern formation] GO:0010468 [regulation of gene expression] GO:0010719 [negative regulation of epithelial to mesenchymal transition] GO:0016568 [chromatin modification] GO:0019216 [regulation of lipid metabolic process] GO:0019218 [regulation of steroid metabolic process] GO:0019904 [protein domain specific binding] GO:0021533 [cell differentiation in hindbrain] GO:0021904 [dorsal/ventral neural tube patterning] GO:0023019 [signal transduction involved in regulation of gene expression] GO:0030154 [cell differentiation] GO:0030193 [regulation of blood coagulation] GO:0030324 [lung development] GO:0031018 [endocrine pancreas development] GO:0032525 [somite rostral/caudal axis specification] GO:0033132 [negative regulation of glucokinase activity] GO:0040019 [positive regulation of embryonic development] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045665 [negative regulation of neuron differentiation] GO:0045666 [positive regulation of neuron differentiation] GO:0045880 [positive regulation of smoothened signaling pathway] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0048468 [cell development] GO:0048646 [anatomical structure formation involved in morphogenesis] GO:0048665 [neuron fate specification] GO:0060441 [epithelial tube branching involved in lung morphogenesis] GO:0060487 [lung epithelial cell differentiation] GO:0061178 [regulation of insulin secretion involved in cellular response to glucose stimulus] GO:0061448 [connective tissue development] GO:0070741 [response to interleukin-6] GO:0071542 [dopaminergic neuron differentiation] GO:0090009 [primitive streak formation] GO:2000049 [positive regulation of cell-cell adhesion mediated by cadherin] GO:2000543 [positive regulation of gastrulation] GO:2000971 [negative regulation of detection of glucose]