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CENPB

CANCER ATLAS

Gene description

 Centromere protein B, 80kDa

Protein class

 Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB011626

GENE INFORMATION

Gene name

 CENPB

Synonyms

Description

 Centromere protein B, 80kDa (HGNC Symbol)

Entrez gene summary

 This gene product is a highly conserved protein that facilitates centromere formation. It is a DNA-binding protein that is derived from transposases of the pogo DNA transposon family. It contains a helix-loop-helix DNA binding motif at the N-terminus, and a dimerization domain at the C-terminus. The DNA binding domain recognizes and binds a 17-bp sequence (CENP-B box) in the centromeric alpha satellite DNA. This protein is proposed to play an important role in the assembly of specific centromere structures in interphase nuclei and on mitotic chromosomes. It is also considered a major centromere autoantigen recognized by sera from patients with anti-centromere antibodies. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 p13

Chromosome location (bp)

 3783851 - 3786690

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000125817 (version 83.38)

Entrez gene

 1059

UniProt

 P07199 (UniProt - Evidence at protein level)

neXtProt

 NX_P07199

Antibodypedia

 CENPB antibodies

PROTEIN BROWSER
CENPB-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CENPB-001
ENSP00000369075
ENST00000379751
P07199 [Direct mapping]
Major centromere autoantigen B
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000775 [chromosome, centromeric region]
GO:0003676 [nucleic acid binding]
GO:0003677 [DNA binding]
GO:0003682 [chromatin binding]
GO:0003696 [satellite DNA binding]
GO:0005634 [nucleus]
GO:0005694 [chromosome]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0019237 [centromeric DNA binding]
GO:0043565 [sequence-specific DNA binding]
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 599 aa
65.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.