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SNRPB

CANCER ATLAS

Gene description

 Small nuclear ribonucleoprotein polypeptides B and B1

Protein class

 Disease related genes, Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Urothelial cancer

STAINING SUMMARY
HPA003482
CAB009610

GENE INFORMATION

Gene name

 SNRPB (HGNC Symbol)

Synonyms

 COD, Sm-B/B', SmB/SmB', snRNP-B, SNRPB1

Description

 Small nuclear ribonucleoprotein polypeptides B and B1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is one of several nuclear proteins that are found in common among U1, U2, U4/U6, and U5 small ribonucleoprotein particles (snRNPs). These snRNPs are involved in pre-mRNA splicing, and the encoded protein may also play a role in pre-mRNA splicing or snRNP structure. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding different isoforms (B and B') have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 p13

Chromosome location (bp)

 2461634 - 2470853

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000125835 (version 83.38)

Entrez gene

 6628

UniProt

 P14678 (UniProt - Evidence at protein level)

neXtProt

 NX_P14678

Antibodypedia

 SNRPB antibodies

PROTEIN BROWSER
SNRPB-001
SNRPB-002
SNRPB-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SNRPB-001
ENSP00000370746
ENST00000381342
P14678 [Direct mapping]
Small nuclear ribonucleoprotein-associated proteins B and B'
Q66K91 [Target identity:100%; Query identity:100%]
Small nuclear ribonucleoprotein-associated protein
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000387 [spliceosomal snRNP assembly]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005682 [U5 snRNP]
GO:0005683 [U7 snRNP]
GO:0005685 [U1 snRNP]
GO:0005686 [U2 snRNP]
GO:0005687 [U4 snRNP]
GO:0005689 [U12-type spliceosomal complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006369 [termination of RNA polymerase II transcription]
GO:0006479 [protein methylation]
GO:0008334 [histone mRNA metabolic process]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0030532 [small nuclear ribonucleoprotein complex]
GO:0031124 [mRNA 3'-end processing]
GO:0034660 [ncRNA metabolic process]
GO:0034709 [methylosome]
GO:0034719 [SMN-Sm protein complex]
GO:0044822 [poly(A) RNA binding]
GO:0046540 [U4/U6 x U5 tri-snRNP complex]
GO:0070062 [extracellular exosome]
GO:0071004 [U2-type prespliceosome]
GO:0071013 [catalytic step 2 spliceosome]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 231 aa
23.7 kDa 		No 0
SNRPB-002
ENSP00000412566
ENST00000438552
P14678 [Direct mapping]
Small nuclear ribonucleoprotein-associated proteins B and B'
Show all
Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000387 [spliceosomal snRNP assembly]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005682 [U5 snRNP]
GO:0005683 [U7 snRNP]
GO:0005685 [U1 snRNP]
GO:0005686 [U2 snRNP]
GO:0005687 [U4 snRNP]
GO:0005689 [U12-type spliceosomal complex]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006369 [termination of RNA polymerase II transcription]
GO:0006479 [protein methylation]
GO:0008334 [histone mRNA metabolic process]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0030532 [small nuclear ribonucleoprotein complex]
GO:0031124 [mRNA 3'-end processing]
GO:0034660 [ncRNA metabolic process]
GO:0034709 [methylosome]
GO:0034719 [SMN-Sm protein complex]
GO:0044822 [poly(A) RNA binding]
GO:0046540 [U4/U6 x U5 tri-snRNP complex]
GO:0070062 [extracellular exosome]
GO:0071004 [U2-type prespliceosome]
GO:0071013 [catalytic step 2 spliceosome]
GO:0071204 [histone pre-mRNA 3'end processing complex]
GO:0071208 [histone pre-mRNA DCP binding]
GO:0098779 [mitophagy in response to mitochondrial depolarization]
Show all
 240 aa
24.6 kDa 		No 0
SNRPB-201
ENSP00000342305
ENST00000339610
A8MT02 [Direct mapping]
Small nuclear ribonucleoprotein-associated proteins B and B'
Show all
   Phobius predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000398 [mRNA splicing, via spliceosome]
GO:0005682 [U5 snRNP]
GO:0005686 [U2 snRNP]
GO:0005737 [cytoplasm]
GO:0046540 [U4/U6 x U5 tri-snRNP complex]
GO:0071004 [U2-type prespliceosome]
Show all
 288 aa
30 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.