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FLRT3

GENERAL INFORMATION

Gene name

 FLRT3

Gene description

 Fibronectin leucine rich transmembrane protein 3

Protein class

 Disease related genes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Mixed
GTEx:Mixed
FANTOM5:Tissue enhanced (kidney)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic and membranous expression in several tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA056033 , CAB026166
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Stomach

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Mixed
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (kidney)

GENE INFORMATION

Gene name

 FLRT3

Synonyms

Description

 Fibronectin leucine rich transmembrane protein 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the fibronectin leucine rich transmembrane protein (FLRT) family. FLRTs may function in cell adhesion and/or receptor signalling. Their protein structures resemble small leucine-rich proteoglycans found in the extracellular matrix. This gene is expressed in many tissues. Two alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2010]

Chromosome

 20

Cytoband

 p12.1

Chromosome location (bp)

 14322988 - 14337616

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000125848 (version 83.38)

Entrez gene

 23767

UniProt

 Q9NZU0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9NZU0

Antibodypedia

 FLRT3 antibodies

PROTEIN BROWSER
FLRT3-001
FLRT3-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
FLRT3-001
ENSP00000367292
ENST00000378053
Q9NZU0 [Direct mapping]
Leucine-rich repeat transmembrane protein FLRT3
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003345 [proepicardium cell migration involved in pericardium morphogenesis]
GO:0005057 [receptor signaling protein activity]
GO:0005104 [fibroblast growth factor receptor binding]
GO:0005515 [protein binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005615 [extracellular space]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005911 [cell-cell junction]
GO:0005925 [focal adhesion]
GO:0007416 [synapse assembly]
GO:0007507 [heart development]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0030674 [protein binding, bridging]
GO:0031175 [neuron projection development]
GO:0035556 [intracellular signal transduction]
GO:0042803 [protein homodimerization activity]
GO:0043679 [axon terminus]
GO:0044295 [axonal growth cone]
GO:0045499 [chemorepellent activity]
GO:0048598 [embryonic morphogenesis]
GO:0048678 [response to axon injury]
GO:0050919 [negative chemotaxis]
GO:0051965 [positive regulation of synapse assembly]
GO:0060322 [head development]
GO:0097060 [synaptic membrane]
GO:0098609 [cell-cell adhesion]
GO:1990138 [neuron projection extension]
Show all
 649 aa
73 kDa 		Yes 1
FLRT3-003
ENSP00000339912
ENST00000341420
Q9NZU0 [Direct mapping]
Leucine-rich repeat transmembrane protein FLRT3
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003345 [proepicardium cell migration involved in pericardium morphogenesis]
GO:0005057 [receptor signaling protein activity]
GO:0005515 [protein binding]
GO:0005578 [proteinaceous extracellular matrix]
GO:0005789 [endoplasmic reticulum membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005925 [focal adhesion]
GO:0007416 [synapse assembly]
GO:0007507 [heart development]
GO:0008543 [fibroblast growth factor receptor signaling pathway]
GO:0030674 [protein binding, bridging]
GO:0031175 [neuron projection development]
GO:0035556 [intracellular signal transduction]
GO:0042803 [protein homodimerization activity]
GO:0043679 [axon terminus]
GO:0044295 [axonal growth cone]
GO:0048598 [embryonic morphogenesis]
GO:0048678 [response to axon injury]
GO:0060322 [head development]
GO:0097060 [synaptic membrane]
GO:0098609 [cell-cell adhesion]
GO:1990138 [neuron projection extension]
Show all
 649 aa
73 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.