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SNRPB2

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GENERAL INFORMATION

Gene name

 SNRPB2

Gene description

 Small nuclear ribonucleoprotein polypeptide B

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nuclear speckles.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nuclear speckles (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA050814
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nuclear speckles.

Main location

 Nuclear speckles (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA050814 HEK 293 Nuclear speckles
HPA050814 MCF7 Nucleoli fibrillar center
Nuclear speckles
HPA050814 U-2 OS Nuclear speckles

GENE INFORMATION

Gene name

 SNRPB2 (HGNC Symbol)

Synonyms

 Msl1

Description

 Small nuclear ribonucleoprotein polypeptide B (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene associates with stem loop IV of U2 small nuclear ribonucleoprotein (U2 snRNP) in the presence of snRNP-A'. The encoded protein may play a role in pre-mRNA splicing. Autoantibodies from patients with systemic lupus erythematosus frequently recognize epitopes on the encoded protein. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 p12.1

Chromosome location (bp)

 16729961 - 16742563

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000125870 (version 83.38)

Entrez gene

 6629

UniProt

 P08579 (UniProt - Evidence at protein level)

neXtProt

 NX_P08579

Antibodypedia

 SNRPB2 antibodies

PROTEIN BROWSER
SNRPB2-001
SNRPB2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SNRPB2-001
ENSP00000246071
ENST00000246071
P08579 [Direct mapping]
U2 small nuclear ribonucleoprotein B''
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Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0000166 [nucleotide binding]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005686 [U2 snRNP]
GO:0005730 [nucleolus]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0035614 [snRNA stem-loop binding]
GO:0071013 [catalytic step 2 spliceosome]
Show all
 225 aa
25.5 kDa 		No 0
SNRPB2-002
ENSP00000367178
ENST00000377943
P08579 [Direct mapping]
U2 small nuclear ribonucleoprotein B''
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0000398 [mRNA splicing, via spliceosome]
GO:0002230 [positive regulation of defense response to virus by host]
GO:0003676 [nucleic acid binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005681 [spliceosomal complex]
GO:0005686 [U2 snRNP]
GO:0005730 [nucleolus]
GO:0008380 [RNA splicing]
GO:0010467 [gene expression]
GO:0035614 [snRNA stem-loop binding]
GO:0071013 [catalytic step 2 spliceosome]
Show all
 225 aa
25.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.