Expression of TBC1D20 in cancer - Summary

CANCER ATLAS

Gene description

TBC1 domain family, member 20

Protein class

Disease related genes, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA043613

GENE INFORMATION
Gene name	TBC1D20 (HGNC Symbol)
Synonyms	C20orf140, dJ852M4.2
Description	TBC1 domain family, member 20 (HGNC Symbol)
Entrez gene summary	This gene encodes a protein that belongs to a family of GTPase activator proteins of Rab-like small GTPases. The encoded protein and its cognate GTPase, Rab1, bind the nonstructural protein 5A (NS5A) of the hepatitis C virus (HCV) to mediate viral replication. Depletion of this protein inhibits replication of the virus and HCV infection. Mutations in this gene are associated with Warburg micro syndrome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Chromosome	20
Cytoband	p13
Chromosome location (bp)	435480 - 462553
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000125875 (version 83.38)
Entrez gene	128637
UniProt	Q96BZ9 (UniProt - Evidence at protein level)
neXtProt	NX_Q96BZ9
Antibodypedia	TBC1D20 antibodies

PROTEIN BROWSER

TBC1D20-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TBC1D20-004 ENSP00000346139 ENST00000354200	Q96BZ9 [Direct mapping] TBC1 domain family member 20 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001675 [acrosome assembly] GO:0002088 [lens development in camera-type eye] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006888 [ER to Golgi vesicle-mediated transport] GO:0007030 [Golgi organization] GO:0007283 [spermatogenesis] GO:0008584 [male gonad development] GO:0017137 [Rab GTPase binding] GO:0019068 [virion assembly] GO:0030173 [integral component of Golgi membrane] GO:0031965 [nuclear membrane] GO:0034389 [lipid particle organization] GO:0043010 [camera-type eye development] GO:0043547 [positive regulation of GTPase activity] GO:0044829 [positive regulation by host of viral genome replication] GO:0046726 [positive regulation by virus of viral protein levels in host cell] GO:0070309 [lens fiber cell morphogenesis] GO:0072520 [seminiferous tubule development] GO:0090110 [cargo loading into COPII-coated vesicle] GO:1902953 [positive regulation of ER to Golgi vesicle-mediated transport] Show all	403 aa 45.9 kDa	No	3