Expression of ITPA in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Inosine triphosphatase (nucleoside triphosphate pyrophosphatase)

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Thyroid cancer

STAINING SUMMARY

HPA022824

GENE INFORMATION
Gene name	ITPA (HGNC Symbol)
Synonyms	C20orf37, dJ794I6.3, HLC14-06-P
Description	Inosine triphosphatase (nucleoside triphosphate pyrophosphatase) (HGNC Symbol)
Entrez gene summary	This gene encodes an inosine triphosphate pyrophosphohydrolase. The encoded protein hydrolyzes inosine triphosphate and deoxyinosine triphosphate to the monophosphate nucleotide and diphosphate. This protein, which is a member of the HAM1 NTPase protein family, is found in the cytoplasm and acts as a homodimer. Defects in the encoded protein can result in inosine triphosphate pyrophosphorylase deficiency which causes an accumulation of ITP in red blood cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]
Chromosome	20
Cytoband	p13
Chromosome location (bp)	3208868 - 3223870
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000125877 (version 83.38)
Entrez gene	3704
UniProt	Q9BY32 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BY32
Antibodypedia	ITPA antibodies

PROTEIN BROWSER

ITPA-002	ITPA-007	ITPA-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ITPA-002 ENSP00000369456 ENST00000380113	Q9BY32 [Direct mapping] Inosine triphosphate pyrophosphatase Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0006193 [ITP catabolic process] GO:0009204 [deoxyribonucleoside triphosphate catabolic process] GO:0016787 [hydrolase activity] GO:0035870 [dITP diphosphatase activity] GO:0036220 [ITP diphosphatase activity] GO:0036222 [XTP diphosphatase activity] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0047429 [nucleoside-triphosphate diphosphatase activity] GO:0051276 [chromosome organization] GO:0055086 [nucleobase-containing small molecule metabolic process] Show all	194 aa 21.4 kDa	No	0
ITPA-007 ENSP00000382732 ENST00000399838	Q9BY32 [Direct mapping] Inosine triphosphate pyrophosphatase Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0009204 [deoxyribonucleoside triphosphate catabolic process] GO:0016787 [hydrolase activity] GO:0035870 [dITP diphosphatase activity] GO:0036220 [ITP diphosphatase activity] GO:0036222 [XTP diphosphatase activity] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0055086 [nucleobase-containing small molecule metabolic process] Show all	153 aa 16.8 kDa	No	0
ITPA-009 ENSP00000413282 ENST00000455664	Q9BY32 [Direct mapping] Inosine triphosphate pyrophosphatase Show all	Enzymes ENZYME proteins Hydrolases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000166 [nucleotide binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0009204 [deoxyribonucleoside triphosphate catabolic process] GO:0016787 [hydrolase activity] GO:0035870 [dITP diphosphatase activity] GO:0036220 [ITP diphosphatase activity] GO:0036222 [XTP diphosphatase activity] GO:0044281 [small molecule metabolic process] GO:0046872 [metal ion binding] GO:0055086 [nucleobase-containing small molecule metabolic process] Show all	177 aa 19.6 kDa	No	0