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ID1

CANCER ATLAS

Gene description

 Inhibitor of DNA binding 1, dominant negative helix-loop-helix protein

Protein class

 Cancer-related genes, Plasma proteins, Predicted secreted proteins, Transcription factors

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
CAB025915

GENE INFORMATION

Gene name

 ID1 (HGNC Symbol)

Synonyms

 bHLHb24, dJ857M17.1.2

Description

 Inhibitor of DNA binding 1, dominant negative helix-loop-helix protein (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors. The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts. This protein may play a role in cell growth, senescence, and differentiation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 20

Cytoband

 q11.21

Chromosome location (bp)

 31605283 - 31606515

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000125968 (version 83.38)

Entrez gene

 3397

UniProt

 P41134 (UniProt - Evidence at protein level)

neXtProt

 NX_P41134

Antibodypedia

 ID1 antibodies

PROTEIN BROWSER
ID1-001
ID1-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ID1-001
ENSP00000365280
ENST00000376112
P41134 [Direct mapping]
DNA-binding protein inhibitor ID-1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Transcription factors
   Basic domains
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0001525 [angiogenesis]
GO:0001886 [endothelial cell morphogenesis]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005813 [centrosome]
GO:0006351 [transcription, DNA-templated]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0007420 [brain development]
GO:0007507 [heart development]
GO:0007623 [circadian rhythm]
GO:0008022 [protein C-terminus binding]
GO:0008134 [transcription factor binding]
GO:0010621 [negative regulation of transcription by transcription factor localization]
GO:0010628 [positive regulation of gene expression]
GO:0014070 [response to organic cyclic compound]
GO:0030182 [neuron differentiation]
GO:0030509 [BMP signaling pathway]
GO:0031648 [protein destabilization]
GO:0032091 [negative regulation of protein binding]
GO:0032233 [positive regulation of actin filament bundle assembly]
GO:0032963 [collagen metabolic process]
GO:0036164 [cell-abiotic substrate adhesion]
GO:0042803 [protein homodimerization activity]
GO:0043066 [negative regulation of apoptotic process]
GO:0043392 [negative regulation of DNA binding]
GO:0043408 [regulation of MAPK cascade]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043534 [blood vessel endothelial cell migration]
GO:0045602 [negative regulation of endothelial cell differentiation]
GO:0045668 [negative regulation of osteoblast differentiation]
GO:0045765 [regulation of angiogenesis]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046677 [response to antibiotic]
GO:0046983 [protein dimerization activity]
GO:0047485 [protein N-terminus binding]
GO:0048511 [rhythmic process]
GO:0048514 [blood vessel morphogenesis]
GO:0050679 [positive regulation of epithelial cell proliferation]
GO:0050774 [negative regulation of dendrite morphogenesis]
GO:0060425 [lung morphogenesis]
GO:0060426 [lung vasculature development]
GO:0070628 [proteasome binding]
GO:0071364 [cellular response to epidermal growth factor stimulus]
GO:0071560 [cellular response to transforming growth factor beta stimulus]
GO:1901342 [regulation of vasculature development]
GO:1901653 [cellular response to peptide]
GO:1903026 [negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding]
GO:1903351 [cellular response to dopamine]
GO:1990090 [cellular response to nerve growth factor stimulus]
Show all
 155 aa
16.1 kDa 		Yes 0
ID1-002
ENSP00000365273
ENST00000376105
P41134 [Direct mapping]
DNA-binding protein inhibitor ID-1
Show all
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Transcription factors
   Basic domains
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001525 [angiogenesis]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005794 [Golgi apparatus]
GO:0006351 [transcription, DNA-templated]
GO:0007179 [transforming growth factor beta receptor signaling pathway]
GO:0010621 [negative regulation of transcription by transcription factor localization]
GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity]
GO:0043534 [blood vessel endothelial cell migration]
GO:0045892 [negative regulation of transcription, DNA-templated]
GO:0046983 [protein dimerization activity]
GO:0048511 [rhythmic process]
GO:0048514 [blood vessel morphogenesis]
Show all
 149 aa
15.6 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.