Expression of EIF2S2 in cancer - Summary

CANCER ATLAS

Gene description

Eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa

Protein class

Cancer-related genes, Plasma proteins, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA041332	CAB034415

GENE INFORMATION
Gene name	EIF2S2 (HGNC Symbol)
Synonyms	EIF2, EIF2beta, PPP1R67
Description	Eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa (HGNC Symbol)
Entrez gene summary	Eukaryotic translation initiation factor 2 (EIF-2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. EIF-2 is composed of three subunits, alpha, beta, and gamma, with the protein encoded by this gene representing the beta subunit. The beta subunit catalyzes the exchange of GDP for GTP, which recycles the EIF-2 complex for another round of initiation. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]
Chromosome	20
Cytoband	q11.22
Chromosome location (bp)	34088298 - 34112332
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000125977 (version 83.38)
Entrez gene	8894
UniProt	P20042 (UniProt - Evidence at protein level)
neXtProt	NX_P20042
Antibodypedia	EIF2S2 antibodies

PROTEIN BROWSER

EIF2S2-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EIF2S2-001 ENSP00000364119 ENST00000374980	P20042 [Direct mapping] Eukaryotic translation initiation factor 2 subunit 2 Q6IBR8 [Target identity:100%; Query identity:100%] EIF2S2 protein; Eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa; Eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa, isoform CRA_b; cDNA, FLJ93495, highly similar to Homo sapiens eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa (EIF2S2), mRNA Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001701 [in utero embryonic development] GO:0002176 [male germ cell proliferation] GO:0003723 [RNA binding] GO:0003743 [translation initiation factor activity] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005829 [cytosol] GO:0005850 [eukaryotic translation initiation factor 2 complex] GO:0006412 [translation] GO:0006413 [translational initiation] GO:0008135 [translation factor activity, RNA binding] GO:0008584 [male gonad development] GO:0010467 [gene expression] GO:0044267 [cellular protein metabolic process] GO:0044822 [poly(A) RNA binding] GO:0046872 [metal ion binding] GO:0055085 [transmembrane transport] Show all	333 aa 38.4 kDa	No	0