Expression of BPIFB1 in cancer - Summary

CANCER ATLAS

Gene description

BPI fold containing family B, member 1

Protein class

Plasma proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA024256

GENE INFORMATION
Gene name	BPIFB1 (HGNC Symbol)
Synonyms	bA49G10.6, C20orf114, dJ1187J4.1, LPLUNC1, MGC14597, VEMSGP
Description	BPI fold containing family B, member 1 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene may be involved in the innate immune response to bacterial exposure in the mouth, nasal cavities, and lungs. The encoded protein is secreted and is a member of the BPI/LBP/PLUNC protein superfamily. This gene is found with other members of the superfamily in a cluster on chromosome 20. [provided by RefSeq, Jul 2008]
Chromosome	20
Cytoband	q11.21
Chromosome location (bp)	33273480 - 33309878
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000125999 (version 83.38)
Entrez gene	92747
UniProt	Q8TDL5 (UniProt - Evidence at protein level)
neXtProt	NX_Q8TDL5
Antibodypedia	BPIFB1 antibodies

PROTEIN BROWSER

BPIFB1-003	BPIFB1-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BPIFB1-003 ENSP00000253354 ENST00000253354	Q8TDL5 [Direct mapping] BPI fold-containing family B member 1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002227 [innate immune response in mucosa] GO:0003674 [molecular_function] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0008289 [lipid binding] GO:0034144 [negative regulation of toll-like receptor 4 signaling pathway] GO:0070062 [extracellular exosome] Show all	484 aa 52.4 kDa	Yes	0
BPIFB1-005 ENSP00000390471 ENST00000423645	A2A2R0 [Direct mapping] BPI fold-containing family B member 1 Show all	MEMSAT3 predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0008289 [lipid binding] Show all	147 aa 15.9 kDa	Yes	0