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Mainly localized to the plasma membrane. In addition localized to the cytosol & nucleoplasm.
Caution: Based on antibodies targeting proteins from multiple genes.
RNA cell category
Expressed in all
Protein evidence
Evidence at protein level
Main location
Localized to the Plasma membrane (uncertain)
Additional location
In addition localized to the Nucleoplasm (uncertain), Cytosol (uncertain)
Cell lines sorted after organ of phenotypic resemblance.
Cell lines sorted after biological source for establishment.
Cell lines sorted after the cell line category according to Cellosaurus.
Cell lines sorted on descending RNA expression.
Cell lines sorted alphabetically.
HUMAN CELLS
Summary
Mainly localized to the plasma membrane. In addition localized to the cytosol & nucleoplasm.
Caution: Based on antibodies targeting proteins from multiple genes.
Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named ""kinesin 2"", this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined. [provided by RefSeq, Jul 2008]