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XRCC3

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GENERAL INFORMATION

Gene name

 XRCC3

Gene description

 X-ray repair complementing defective repair in Chinese hamster cells 3

Protein class

 Cancer-related genes
Disease related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 11
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleus.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (validated)

Single-cell variation

 Single-cell variation in protein expression observed.

GFP

 The location(s) are Validated based on analysis of GFP-tagged protein.

DATA RELIABILITY

Reliability score

 Validated based on 2 antibodies.
HPA062422 , HPA068953
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ASSAYS
RNA expression
Human cells
GFP

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleus.

Main location

 Nucleus (validated)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA062422 MCF7 Nucleus
HPA062422 PC-3 Nucleus Intensity
HPA062422 U-2 OS Nucleus Intensity
HPA068953 HaCaT Nucleoplasm
HPA068953 RH-30 Nucleoplasm
Cytosol
HPA068953 U-2 OS No staining    

GFP

Antibody

 HPA062422

Validation

C-terminal tag
BAC cell line: 6109
Validated: Antibody staining overlaps with GFP tagged protein

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

BAC id

Tag

Location antibody staining

Location tagged protein
HPA062422 HeLa 6109 C-terminal Nucleoplasm Nucleoplasm
HPA062422 HeLa Normal - Nucleoplasm -

GENE INFORMATION

Gene name

 XRCC3

Synonyms

Description

 X-ray repair complementing defective repair in Chinese hamster cells 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene functionally complements Chinese hamster irs1SF, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents and is chromosomally unstable. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]

Chromosome

 14

Cytoband

 q32.33

Chromosome location (bp)

 103697609 - 103715504

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000126215 (version 83.38)

Entrez gene

 7517

UniProt

 O43542 (UniProt - Evidence at protein level)

neXtProt

 NX_O43542

Antibodypedia

 XRCC3 antibodies

PROTEIN BROWSER
«
XRCC3-001
XRCC3-002
XRCC3-003
XRCC3-005
XRCC3-007
XRCC3-008
XRCC3-009
XRCC3-011
XRCC3-012
XRCC3-013
XRCC3-014
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
XRCC3-001
ENSP00000343392
ENST00000352127
O43542 [Direct mapping]
DNA repair protein XRCC3
Q53XC8 [Target identity:100%; Query identity:100%]
Full-length cDNA clone CS0DC014YE11 of Neuroblastoma of Homo sapiens (human); X-ray repair complementing defective repair in Chinese hamster cells 3; X-ray repair complementing defective repair in Chinese hamster cells 3, isoform CRA_a; cDNA FLJ12767 fis, clone NT2RP2001536, highly similar to DNA-repair protein XRCC3; cDNA FLJ13584 fis, clone PLACE1009113, highly similar to DNA-repair protein XRCC3; cDNA FLJ42507 fis, clone BRACE2040514, highly similar to DNA-repair protein XRCC3
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000150 [recombinase activity]
GO:0000400 [four-way junction DNA binding]
GO:0000707 [meiotic DNA recombinase assembly]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0003677 [DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005657 [replication fork]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006310 [DNA recombination]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007131 [reciprocal meiotic recombination]
GO:0008094 [DNA-dependent ATPase activity]
GO:0008821 [crossover junction endodeoxyribonuclease activity]
GO:0010212 [response to ionizing radiation]
GO:0010824 [regulation of centrosome duplication]
GO:0033063 [Rad51B-Rad51C-Rad51D-XRCC2 complex]
GO:0033065 [Rad51C-XRCC3 complex]
GO:0042148 [strand invasion]
GO:0045003 [double-strand break repair via synthesis-dependent strand annealing]
GO:0048471 [perinuclear region of cytoplasm]
GO:0071140 [resolution of mitotic recombination intermediates]
GO:0090267 [positive regulation of mitotic cell cycle spindle assembly checkpoint]
Show all
 346 aa
37.8 kDa 		No 0
XRCC3-002
ENSP00000452598
ENST00000555055
O43542 [Direct mapping]
DNA repair protein XRCC3
Q53XC8 [Target identity:100%; Query identity:100%]
Full-length cDNA clone CS0DC014YE11 of Neuroblastoma of Homo sapiens (human); X-ray repair complementing defective repair in Chinese hamster cells 3; X-ray repair complementing defective repair in Chinese hamster cells 3, isoform CRA_a; cDNA FLJ12767 fis, clone NT2RP2001536, highly similar to DNA-repair protein XRCC3; cDNA FLJ13584 fis, clone PLACE1009113, highly similar to DNA-repair protein XRCC3; cDNA FLJ42507 fis, clone BRACE2040514, highly similar to DNA-repair protein XRCC3
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000150 [recombinase activity]
GO:0000400 [four-way junction DNA binding]
GO:0000707 [meiotic DNA recombinase assembly]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0003677 [DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005657 [replication fork]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006310 [DNA recombination]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007131 [reciprocal meiotic recombination]
GO:0008094 [DNA-dependent ATPase activity]
GO:0008821 [crossover junction endodeoxyribonuclease activity]
GO:0010212 [response to ionizing radiation]
GO:0010824 [regulation of centrosome duplication]
GO:0033063 [Rad51B-Rad51C-Rad51D-XRCC2 complex]
GO:0033065 [Rad51C-XRCC3 complex]
GO:0042148 [strand invasion]
GO:0045003 [double-strand break repair via synthesis-dependent strand annealing]
GO:0048471 [perinuclear region of cytoplasm]
GO:0071140 [resolution of mitotic recombination intermediates]
GO:0090267 [positive regulation of mitotic cell cycle spindle assembly checkpoint]
Show all
 346 aa
37.8 kDa 		No 0
XRCC3-003
ENSP00000451974
ENST00000553264
O43542 [Direct mapping]
DNA repair protein XRCC3
Q53XC8 [Target identity:100%; Query identity:100%]
Full-length cDNA clone CS0DC014YE11 of Neuroblastoma of Homo sapiens (human); X-ray repair complementing defective repair in Chinese hamster cells 3; X-ray repair complementing defective repair in Chinese hamster cells 3, isoform CRA_a; cDNA FLJ12767 fis, clone NT2RP2001536, highly similar to DNA-repair protein XRCC3; cDNA FLJ13584 fis, clone PLACE1009113, highly similar to DNA-repair protein XRCC3; cDNA FLJ42507 fis, clone BRACE2040514, highly similar to DNA-repair protein XRCC3
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000150 [recombinase activity]
GO:0000400 [four-way junction DNA binding]
GO:0000707 [meiotic DNA recombinase assembly]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0003677 [DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005657 [replication fork]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006310 [DNA recombination]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007131 [reciprocal meiotic recombination]
GO:0008094 [DNA-dependent ATPase activity]
GO:0008821 [crossover junction endodeoxyribonuclease activity]
GO:0010033 [response to organic substance]
GO:0010212 [response to ionizing radiation]
GO:0010824 [regulation of centrosome duplication]
GO:0033063 [Rad51B-Rad51C-Rad51D-XRCC2 complex]
GO:0033065 [Rad51C-XRCC3 complex]
GO:0042148 [strand invasion]
GO:0045003 [double-strand break repair via synthesis-dependent strand annealing]
GO:0048471 [perinuclear region of cytoplasm]
GO:0071140 [resolution of mitotic recombination intermediates]
GO:0090267 [positive regulation of mitotic cell cycle spindle assembly checkpoint]
Show all
 346 aa
37.8 kDa 		No 0
XRCC3-005
ENSP00000451362
ENST00000554913
O43542 [Direct mapping]
DNA repair protein XRCC3
Q53XC8 [Target identity:100%; Query identity:100%]
Full-length cDNA clone CS0DC014YE11 of Neuroblastoma of Homo sapiens (human); X-ray repair complementing defective repair in Chinese hamster cells 3; X-ray repair complementing defective repair in Chinese hamster cells 3, isoform CRA_a; cDNA FLJ12767 fis, clone NT2RP2001536, highly similar to DNA-repair protein XRCC3; cDNA FLJ13584 fis, clone PLACE1009113, highly similar to DNA-repair protein XRCC3; cDNA FLJ42507 fis, clone BRACE2040514, highly similar to DNA-repair protein XRCC3
Show all
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000150 [recombinase activity]
GO:0000400 [four-way junction DNA binding]
GO:0000707 [meiotic DNA recombinase assembly]
GO:0000724 [double-strand break repair via homologous recombination]
GO:0003677 [DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003697 [single-stranded DNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005657 [replication fork]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006281 [DNA repair]
GO:0006302 [double-strand break repair]
GO:0006310 [DNA recombination]
GO:0006974 [cellular response to DNA damage stimulus]
GO:0007131 [reciprocal meiotic recombination]
GO:0008094 [DNA-dependent ATPase activity]
GO:0008821 [crossover junction endodeoxyribonuclease activity]
GO:0010212 [response to ionizing radiation]
GO:0010824 [regulation of centrosome duplication]
GO:0033063 [Rad51B-Rad51C-Rad51D-XRCC2 complex]
GO:0033065 [Rad51C-XRCC3 complex]
GO:0042148 [strand invasion]
GO:0045003 [double-strand break repair via synthesis-dependent strand annealing]
GO:0048471 [perinuclear region of cytoplasm]
GO:0071140 [resolution of mitotic recombination intermediates]
GO:0090267 [positive regulation of mitotic cell cycle spindle assembly checkpoint]
Show all
 346 aa
37.8 kDa 		No 0
XRCC3-007
ENSP00000450780
ENST00000553332
G3V2P3 [Direct mapping]
DNA repair protein XRCC3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 47 aa
5.3 kDa 		No 0
XRCC3-008
ENSP00000451173
ENST00000555964
G3V3C8 [Direct mapping]
DNA repair protein XRCC3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 102 aa
11.4 kDa 		No 0
XRCC3-009
ENSP00000452389
ENST00000556682
G3V5K0 [Direct mapping]
DNA repair protein XRCC3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 61 aa
6.8 kDa 		No 0
XRCC3-011
ENSP00000451118
ENST00000553361
G3V399 [Direct mapping]
DNA repair protein XRCC3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005524 [ATP binding]
GO:0006281 [DNA repair]
GO:0008094 [DNA-dependent ATPase activity]
Show all
 150 aa
16.6 kDa 		No 0
XRCC3-012
ENSP00000451361
ENST00000554974
G3V3Q2 [Direct mapping]
DNA repair protein XRCC3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005524 [ATP binding]
GO:0006281 [DNA repair]
GO:0008094 [DNA-dependent ATPase activity]
Show all
 141 aa
15.1 kDa 		No 0
XRCC3-013
ENSP00000451252
ENST00000556980
G3V3H9 [Direct mapping]
DNA repair protein XRCC3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0005524 [ATP binding]
GO:0006281 [DNA repair]
GO:0008094 [DNA-dependent ATPase activity]
Show all
 112 aa
12.3 kDa 		No 0
XRCC3-014
ENSP00000450738
ENST00000554170
G3V2L7 [Direct mapping]
DNA repair protein XRCC3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 45 aa
5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.