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SLURP1

GENERAL INFORMATION

Gene name

 SLURP1

Gene description

 Secreted LY6/PLAUR domain containing 1

Protein class

 Disease related genes
Plasma proteins
Predicted secreted proteins

Predicted localization

 Secreted

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (esophagus, skin)
GTEx:Group enriched (esophagus, skin, vagina)
FANTOM5:Group enriched (esophagus, tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Membranous and cytoplasmic expression in several squamous epithelia.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Approved based on 1 antibody.
HPA050967
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (esophagus, skin)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (esophagus, skin, vagina)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (esophagus, tonsil)

GENE INFORMATION

Gene name

 SLURP1 (HGNC Symbol)

Synonyms

 ANUP, ARS, ArsB, LY6LS, MDM

Description

 Secreted LY6/PLAUR domain containing 1 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the Ly6/uPAR family but lacks a GPI-anchoring signal sequence. It is thought that this secreted protein contains antitumor activity. Mutations in this gene have been associated with Mal de Meleda, a rare autosomal recessive skin disorder. This gene maps to the same chromosomal region as several members of the Ly6/uPAR family of glycoprotein receptors. [provided by RefSeq, Jul 2008]

Chromosome

 8

Cytoband

 q24.3

Chromosome location (bp)

 142740944 - 142742411

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000126233 (version 83.38)

Entrez gene

 57152

UniProt

 P55000 (UniProt - Evidence at protein level)

neXtProt

 NX_P55000

Antibodypedia

 SLURP1 antibodies

PROTEIN BROWSER
SLURP1-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLURP1-001
ENSP00000246515
ENST00000246515
P55000 [Direct mapping]
Secreted Ly-6/uPAR-related protein 1
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   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001775 [cell activation]
GO:0005125 [cytokine activity]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0007155 [cell adhesion]
GO:0007626 [locomotory behavior]
GO:0010839 [negative regulation of keratinocyte proliferation]
GO:0050884 [neuromuscular process controlling posture]
GO:0070062 [extracellular exosome]
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 103 aa
11.2 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.