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Malignant tissues were generally negative. Malignant lymphomas displayed strong cytoplasmic and membranous immunoreactivity. A few head and neck cancers showed strong cytoplasmic staining.
GENE INFORMATION
Gene name
CCR7 (HGNC Symbol)
Synonyms
BLR2, CD197, CDw197, CMKBR7, EBI1
Description
Chemokine (C-C motif) receptor 7 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]