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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Tissue

Detectable

Cell line

Detectable

Category

Score

Score

Score

Antibodies

Column

 
 
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CCR7
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    TISSUE

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    CELL

  • CANCER

CANCER ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

CANCER ATLASi

The cancer tissue page shows antibody staining in 20 different cancers. The assay and annotation is described here.

This page starts with information about the protein evidence and, when applicable, also protein class. Below the summary, a selection of four standard cancer tissue samples is displayed as representative of the overall staining pattern. From left: colorectal cancer, breast cancer, prostate cancer and lung cancer. An additional 5th image can be added as a complement.

For histological reference, visit the histological dictionary.

Gene description

Chemokine (C-C motif) receptor 7

Protein class

Cancer-related genes, CD markers, G-protein coupled receptors, Predicted membrane proteins

Protein evidence

Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Lymphoma

STAINING SUMMARYi

The cancer tissue summary page shows antibody staining in 20 different cancers. The assay and annotation is described here.

For each cancer, the fraction of samples with antibody staining/protein expression level high, medium, low, or not detected are provided by the blue-scale color-coding (as described by the color-coding scale in the box to the right). The length of the bar represents the number of patient samples analyzed (max=12 patients). The images and annotations can be accessed by clicking on the cancer name or protein expression bar. If more than one antibody is analyzed, the tabs at the top of the staining summary section can be used to toggle between the different antibodies. The tooltip function displays additional data for the features in the staining summary view.

Next to the cancer staining data, the protein expression data of normal tissues or specific cell types corresponding to each cancer are shown and protein expression levels are indicated by the blue-scale color coding.

At the bottom of the page, a summary of the overall protein expression pattern across the analyzed cancer tissues as well as information about literature conformity are presented.

CAB003796

Tissue

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Tissue

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Malignant tissues were generally negative. Malignant lymphomas displayed strong cytoplasmic and membranous immunoreactivity. A few head and neck cancers showed strong cytoplasmic staining.

GENE INFORMATIONi

Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.

Gene name

CCR7 (HGNC Symbol)

Synonyms

BLR2, CD197, CDw197, CMKBR7, EBI1

Description

Chemokine (C-C motif) receptor 7 (HGNC Symbol)

Entrez gene summary

The protein encoded by this gene is a member of the G protein-coupled receptor family. This receptor was identified as a gene induced by the Epstein-Barr virus (EBV), and is thought to be a mediator of EBV effects on B lymphocytes. This receptor is expressed in various lymphoid tissues and activates B and T lymphocytes. It has been shown to control the migration of memory T cells to inflamed tissues, as well as stimulate dendritic cell maturation. The chemokine (C-C motif) ligand 19 (CCL19/ECL) has been reported to be a specific ligand of this receptor. Signals mediated by this receptor regulate T cell homeostasis in lymph nodes, and may also function in the activation and polarization of T cells, and in chronic inflammation pathogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]

Chromosome

17

Cytoband

q21.2

Chromosome location (bp)

40553769 - 40565472

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000126353 (version 83.38)

Entrez gene

1236

UniProt

P32248 (UniProt - Evidence at transcript level)

neXtProt

NX_P32248

Antibodypedia

CCR7 antibodies

PROTEIN BROWSERi

The protein browser displays the antigen location on the target protein(s) and the features of the target protein. The tabs at the top of the protein view section can be used to switch between the different splice variants to which an antigen has been mapped.

At the top of the view, the position of the antigen (identified by the corresponding HPA identifier) is shown as a green bar. A yellow triangle on the bar indicates a <100% sequence identity to the protein target.

Under the antigens, the maximum percent sequence identity of the protein to all other proteins from other human genes is displayed, using a sliding window of 10 aa residues (HsID 10) or 50 aa residues (HsID 50) (read more).

If a signal peptide is predicted by a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius (turquoise) and/or transmembrane regions (orange) are predicted by MDM, these are displayed.

Low complexity regions are shown in yellow and InterPro regions in green. Common (purple) and unique (grey) regions between different splice variants of the gene are also displayed (read more), and at the bottom of the protein view is the protein scale.

CCR7-001
CCR7-002
CCR7-003

PROTEIN INFORMATIONi

The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database.

The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein.

The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class.

The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

CCR7-001
ENSP00000246657
ENST00000246657
P32248 [Direct mapping]
C-C chemokine receptor type 7
A0N0Q0 [Target identity:100%; Query identity:100%]
Chemokine (C-C motif) receptor 7; cDNA FLJ45911 fis, clone PEBLM2005615, highly similar to C-C chemokine receptor type 7
Show all
CD markers
G-protein coupled receptors
   GPCRs excl olfactory receptors
   Chemokines and chemotactic factors receptors
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001768 [establishment of T cell polarity]
GO:0001954 [positive regulation of cell-matrix adhesion]
GO:0002407 [dendritic cell chemotaxis]
GO:0002408 [myeloid dendritic cell chemotaxis]
GO:0002606 [positive regulation of dendritic cell antigen processing and presentation]
GO:0002885 [positive regulation of hypersensitivity]
GO:0002922 [positive regulation of humoral immune response]
GO:0004930 [G-protein coupled receptor activity]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007204 [positive regulation of cytosolic calcium ion concentration]
GO:0009897 [external side of plasma membrane]
GO:0009986 [cell surface]
GO:0016021 [integral component of membrane]
GO:0016493 [C-C chemokine receptor activity]
GO:0030838 [positive regulation of actin filament polymerization]
GO:0031274 [positive regulation of pseudopodium assembly]
GO:0031529 [ruffle organization]
GO:0032496 [response to lipopolysaccharide]
GO:0032649 [regulation of interferon-gamma production]
GO:0032735 [positive regulation of interleukin-12 production]
GO:0034695 [response to prostaglandin E]
GO:0035757 [chemokine (C-C motif) ligand 19 binding]
GO:0035758 [chemokine (C-C motif) ligand 21 binding]
GO:0038115 [chemokine (C-C motif) ligand 19 signaling pathway]
GO:0038116 [chemokine (C-C motif) ligand 21 signaling pathway]
GO:0038117 [C-C motif chemokine 19 receptor activity]
GO:0038121 [C-C motif chemokine 21 receptor activity]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043552 [positive regulation of phosphatidylinositol 3-kinase activity]
GO:0045060 [negative thymic T cell selection]
GO:0045785 [positive regulation of cell adhesion]
GO:0045860 [positive regulation of protein kinase activity]
GO:0046330 [positive regulation of JNK cascade]
GO:0048872 [homeostasis of number of cells]
GO:0050706 [regulation of interleukin-1 beta secretion]
GO:0050862 [positive regulation of T cell receptor signaling pathway]
GO:0051209 [release of sequestered calcium ion into cytosol]
GO:0051491 [positive regulation of filopodium assembly]
GO:0051897 [positive regulation of protein kinase B signaling]
GO:0070098 [chemokine-mediated signaling pathway]
GO:0070374 [positive regulation of ERK1 and ERK2 cascade]
GO:0071345 [cellular response to cytokine stimulus]
GO:0071731 [response to nitric oxide]
GO:0072610 [interleukin-12 secretion]
GO:0090023 [positive regulation of neutrophil chemotaxis]
GO:0090630 [activation of GTPase activity]
GO:0097022 [lymphocyte migration into lymph node]
GO:0097029 [mature conventional dendritic cell differentiation]
GO:2000107 [negative regulation of leukocyte apoptotic process]
GO:2000147 [positive regulation of cell motility]
GO:2000510 [positive regulation of dendritic cell chemotaxis]
GO:2000522 [positive regulation of immunological synapse formation]
GO:2000525 [positive regulation of T cell costimulation]
GO:2000526 [positive regulation of glycoprotein biosynthetic process involved in immunological synapse formation]
GO:2000547 [regulation of dendritic cell dendrite assembly]
Show all
378 aa
42.9 kDa
Yes 7
CCR7-002
ENSP00000462631
ENST00000579344
J3KSS9 [Direct mapping]
C-C chemokine receptor type 7
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   GPCRHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0016493 [C-C chemokine receptor activity]
GO:0070098 [chemokine-mediated signaling pathway]
Show all
372 aa
42.2 kDa
Yes 7
CCR7-003
ENSP00000463075
ENST00000578085
J3KTN5 [Direct mapping]
C-C chemokine receptor type 7
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   5TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004930 [G-protein coupled receptor activity]
GO:0006935 [chemotaxis]
GO:0006954 [inflammatory response]
GO:0006955 [immune response]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0016021 [integral component of membrane]
GO:0016493 [C-C chemokine receptor activity]
GO:0070098 [chemokine-mediated signaling pathway]
Show all
199 aa
22.6 kDa
No 5

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The Human Protein Atlas project is funded
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