Cell atlas - GLIS2 - The Human Protein Atlas

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GLIS2

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm
	Plasma membrane

Human cell
	Cytosol
	Nucleoplasm
	Plasma Membrane

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GENERAL INFORMATION
Gene name	GLIS2
Gene description	GLIS family zinc finger 2
Protein class	Disease related genes Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane, cytosol & nucleoplasm.
RNA cell category	Cell line enhanced (U-2197)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (approved), Plasma membrane (approved), Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA056976
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (U-2197) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane, cytosol & nucleoplasm.

Main location

Nucleoplasm (approved), Plasma membrane (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA056976	HeLa	Nucleoplasm
			Plasma membrane
			Cytosol
	HPA056976	MCF7	No staining
	HPA056976	U-2 OS	No staining

GENE INFORMATION
Gene name	GLIS2 (HGNC Symbol)
Synonyms	NPHP7
Description	GLIS family zinc finger 2 (HGNC Symbol)
Entrez gene summary	This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear transcription factor with five C2H2-type zinc finger domains. The protein encoded by this gene is widely expressed at low levels in the neural tube and peripheral nervous system and likely promotes neuronal differentiation. It is abundantly expressed in the kidney and may have a role in the regulation of kidney morphogenesis. p120 regulates the expression level of this protein and induces the cleavage of this protein's C-terminal zinc finger domain. This protein also promotes the nuclear translocation of p120. Mutations in this gene cause nephronophthisis (NPHP), an autosomal recessive kidney disease characterized by tubular basement membrane disruption, interstitial lymphohistiocytic cell infiltration, and development of cysts at the corticomedullary border of the kidneys.[provided by RefSeq, Jan 2010]
Chromosome	16
Cytoband	p13.3
Chromosome location (bp)	4314761 - 4339597
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000126603 (version 83.38)
Entrez gene	84662
UniProt	Q9BZE0 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BZE0
Antibodypedia	GLIS2 antibodies

PROTEIN BROWSER

GLIS2-001	GLIS2-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GLIS2-001 ENSP00000262366 ENST00000262366	Q9BZE0 [Direct mapping] Zinc finger protein GLIS2 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0006366 [transcription from RNA polymerase II promoter] GO:0007399 [nervous system development] GO:0016607 [nuclear speck] GO:0030154 [cell differentiation] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0044212 [transcription regulatory region DNA binding] GO:0045879 [negative regulation of smoothened signaling pathway] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] Show all	524 aa 55.7 kDa	No	0
GLIS2-201 ENSP00000395547 ENST00000433375	Q9BZE0 [Direct mapping] Zinc finger protein GLIS2 Show all	Predicted intracellular proteins Transcription factors Zinc-coordinating DNA-binding domains Disease related genes Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0007399 [nervous system development] GO:0016607 [nuclear speck] GO:0030154 [cell differentiation] GO:0043433 [negative regulation of sequence-specific DNA binding transcription factor activity] GO:0044212 [transcription regulatory region DNA binding] GO:0045879 [negative regulation of smoothened signaling pathway] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] Show all	524 aa 55.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.