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ELK1

CANCER ATLAS

Gene description

 ELK1, member of ETS oncogene family

Protein class

 Predicted intracellular proteins, RAS pathway related proteins, Transcription factors

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA036084
CAB003808

GENE INFORMATION

Gene name

 ELK1

Synonyms

Description

 ELK1, member of ETS oncogene family (HGNC Symbol)

Entrez gene summary

 This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is a nuclear target for the ras-raf-MAPK signaling cascade. This gene produces multiple isoforms by using alternative translational start codons and by alternative splicing. Related pseudogenes have been identified on chromosomes 7 and 14. [provided by RefSeq, Mar 2012]

Chromosome

 X

Cytoband

 p11.23

Chromosome location (bp)

 47635521 - 47650604

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000126767 (version 83.38)

Entrez gene

 2002

UniProt

 P19419 (UniProt - Evidence at protein level)

neXtProt

 NX_P19419

Antibodypedia

 ELK1 antibodies

PROTEIN BROWSER
ELK1-001
ELK1-002
ELK1-003

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ELK1-001
ENSP00000247161
ENST00000247161
P19419 [Direct mapping]
ETS domain-containing protein Elk-1
A0A024R1A7 [Target identity:100%; Query identity:100%]
ELK1, member of ETS oncogene family, isoform CRA_a
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001047 [core promoter binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0003682 [chromatin binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0009416 [response to light stimulus]
GO:0030154 [cell differentiation]
GO:0030425 [dendrite]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0043025 [neuronal cell body]
GO:0043565 [sequence-specific DNA binding]
GO:0043679 [axon terminus]
GO:0045087 [innate immune response]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051403 [stress-activated MAPK cascade]
GO:0071394 [cellular response to testosterone stimulus]
GO:0071396 [cellular response to lipid]
GO:0071480 [cellular response to gamma radiation]
GO:0071774 [response to fibroblast growth factor]
GO:1901216 [positive regulation of neuron death]
Show all
 428 aa
44.9 kDa 		No 0
ELK1-002
ENSP00000366182
ENST00000376983
P19419 [Direct mapping]
ETS domain-containing protein Elk-1
A0A024R1A7 [Target identity:100%; Query identity:100%]
ELK1, member of ETS oncogene family, isoform CRA_a
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0030154 [cell differentiation]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045087 [innate immune response]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051403 [stress-activated MAPK cascade]
GO:0071774 [response to fibroblast growth factor]
Show all
 428 aa
44.9 kDa 		No 0
ELK1-003
ENSP00000345585
ENST00000343894
P19419 [Direct mapping]
ETS domain-containing protein Elk-1
Show all
Predicted intracellular proteins
Transcription factors
   Helix-turn-helix domains
RAS pathway related proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000978 [RNA polymerase II core promoter proximal region sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0002224 [toll-like receptor signaling pathway]
GO:0002755 [MyD88-dependent toll-like receptor signaling pathway]
GO:0002756 [MyD88-independent toll-like receptor signaling pathway]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0030154 [cell differentiation]
GO:0034134 [toll-like receptor 2 signaling pathway]
GO:0034138 [toll-like receptor 3 signaling pathway]
GO:0034142 [toll-like receptor 4 signaling pathway]
GO:0034146 [toll-like receptor 5 signaling pathway]
GO:0034162 [toll-like receptor 9 signaling pathway]
GO:0034166 [toll-like receptor 10 signaling pathway]
GO:0035666 [TRIF-dependent toll-like receptor signaling pathway]
GO:0038123 [toll-like receptor TLR1:TLR2 signaling pathway]
GO:0038124 [toll-like receptor TLR6:TLR2 signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0045087 [innate immune response]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0048011 [neurotrophin TRK receptor signaling pathway]
GO:0051403 [stress-activated MAPK cascade]
GO:0071774 [response to fibroblast growth factor]
Show all
 95 aa
11.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.