Expression of TIMM17B in cancer - Summary

CANCER ATLAS

Gene description

Translocase of inner mitochondrial membrane 17 homolog B (yeast)

Protein class

Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA029093

GENE INFORMATION
Gene name	TIMM17B (HGNC Symbol)
Synonyms	DXS9822, JM3
Description	Translocase of inner mitochondrial membrane 17 homolog B (yeast) (HGNC Symbol)
Entrez gene summary	This gene encodes a multipass transmembrane protein that forms an integral component of the mitochondrial translocase TIM23 complex. This complex facilitates the transport of mitochondrial proteins from the cytosol across the mitochondrial inner membrane and into the mitochondrion. There is a pseudogene for this gene on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Chromosome	X
Cytoband	p11.23
Chromosome location (bp)	48893447 - 48898143
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000126768 (version 83.38)
Entrez gene	10245
UniProt	O60830 (UniProt - Evidence at protein level)
neXtProt	NX_O60830
Antibodypedia	TIMM17B antibodies

PROTEIN BROWSER

TIMM17B-001	TIMM17B-002	TIMM17B-006	TIMM17B-008	TIMM17B-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TIMM17B-001 ENSP00000365766 ENST00000376582	O60830 [Direct mapping] Mitochondrial import inner membrane translocase subunit Tim17-B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005743 [mitochondrial inner membrane] GO:0005744 [mitochondrial inner membrane presequence translocase complex] GO:0006626 [protein targeting to mitochondrion] GO:0006886 [intracellular protein transport] GO:0015266 [protein channel activity] GO:0015450 [P-P-bond-hydrolysis-driven protein transmembrane transporter activity] GO:0030150 [protein import into mitochondrial matrix] GO:0031305 [integral component of mitochondrial inner membrane] GO:0044267 [cellular protein metabolic process] Show all	172 aa 18.3 kDa	No	2
TIMM17B-002 ENSP00000477027 ENST00000495490	V9GYS0 [Direct mapping] Mitochondrial import inner membrane translocase subunit Tim17-B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	192 aa 20.4 kDa	No	3
TIMM17B-006 ENSP00000477085 ENST00000490755	V9GYU0 [Direct mapping] Mitochondrial import inner membrane translocase subunit Tim17-B Show all	MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	159 aa 17 kDa	No	0
TIMM17B-008 ENSP00000477073 ENST00000465150	O60830 [Direct mapping] Mitochondrial import inner membrane translocase subunit Tim17-B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005743 [mitochondrial inner membrane] GO:0005744 [mitochondrial inner membrane presequence translocase complex] GO:0006626 [protein targeting to mitochondrion] GO:0015266 [protein channel activity] GO:0015450 [P-P-bond-hydrolysis-driven protein transmembrane transporter activity] GO:0030150 [protein import into mitochondrial matrix] GO:0031305 [integral component of mitochondrial inner membrane] GO:0044267 [cellular protein metabolic process] Show all	222 aa 23.8 kDa	No	2
TIMM17B-201 ENSP00000379999 ENST00000396779	O60830 [Direct mapping] Mitochondrial import inner membrane translocase subunit Tim17-B Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005739 [mitochondrion] GO:0005743 [mitochondrial inner membrane] GO:0005744 [mitochondrial inner membrane presequence translocase complex] GO:0006626 [protein targeting to mitochondrion] GO:0015266 [protein channel activity] GO:0015450 [P-P-bond-hydrolysis-driven protein transmembrane transporter activity] GO:0030150 [protein import into mitochondrial matrix] GO:0031305 [integral component of mitochondrial inner membrane] GO:0044267 [cellular protein metabolic process] Show all	222 aa 23.8 kDa	No	2