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ZBTB1

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GENERAL INFORMATION

Gene name

 ZBTB1

Gene description

 Zinc finger and BTB domain containing 1

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nuclear membrane & nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (supported), Nuclear membrane (supported)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA050516
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ASSAYS
RNA expression
Human cells
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nuclear membrane & nucleoplasm.

Main location

 Nucleoplasm (supported), Nuclear membrane (supported)

 

 

 
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Low
High
G1
S
G2
M
N/A

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Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA050516 A-431 Nucleoplasm
Nuclear membrane
HPA050516 MCF7 Nucleoplasm
Nuclear membrane
HPA050516 U-2 OS Nucleoplasm
Nuclear membrane

MOUSE CELLS

Main location

 Not available

Mouse gene

 ENSMUSG00000033454 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

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Antibody

Cell line

Location
HPA050516 NIH 3T3 Nucleoplasm
Nuclear membrane

GENE INFORMATION

Gene name

 ZBTB1 (HGNC Symbol)

Synonyms

 KIAA0997, ZNF909

Description

 Zinc finger and BTB domain containing 1 (HGNC Symbol)

Entrez gene summary

Chromosome

 14

Cytoband

 q23.3

Chromosome location (bp)

 64503712 - 64533690

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000126804 (version 83.38)

Entrez gene

 22890

UniProt

 Q9Y2K1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9Y2K1

Antibodypedia

 ZBTB1 antibodies

PROTEIN BROWSER
ZBTB1-001
ZBTB1-002
ZBTB1-003
ZBTB1-004
ZBTB1-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ZBTB1-001
ENSP00000351587
ENST00000358738
Q9Y2K1 [Direct mapping]
Zinc finger and BTB domain-containing protein 1
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0002711 [positive regulation of T cell mediated immunity]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0016604 [nuclear body]
GO:0032825 [positive regulation of natural killer cell differentiation]
GO:0042789 [mRNA transcription from RNA polymerase II promoter]
GO:0042803 [protein homodimerization activity]
GO:0045087 [innate immune response]
GO:0045582 [positive regulation of T cell differentiation]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0048538 [thymus development]
GO:0051260 [protein homooligomerization]
GO:2000176 [positive regulation of pro-T cell differentiation]
Show all
 644 aa
73.7 kDa 		No 0
ZBTB1-002
ENSP00000451000
ENST00000554015
Q9Y2K1 [Direct mapping]
Zinc finger and BTB domain-containing protein 1
Show all
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0002711 [positive regulation of T cell mediated immunity]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0016604 [nuclear body]
GO:0030183 [B cell differentiation]
GO:0032825 [positive regulation of natural killer cell differentiation]
GO:0033077 [T cell differentiation in thymus]
GO:0042789 [mRNA transcription from RNA polymerase II promoter]
GO:0042803 [protein homodimerization activity]
GO:0045087 [innate immune response]
GO:0045582 [positive regulation of T cell differentiation]
GO:0046872 [metal ion binding]
GO:0046982 [protein heterodimerization activity]
GO:0048538 [thymus development]
GO:0051260 [protein homooligomerization]
GO:2000176 [positive regulation of pro-T cell differentiation]
Show all
 713 aa
82 kDa 		No 0
ZBTB1-003
ENSP00000451332
ENST00000555321
G3V3N0 [Direct mapping]
Zinc finger and BTB domain-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 34 aa
4 kDa 		No 0
ZBTB1-004
ENSP00000451584
ENST00000553583
G3V447 [Direct mapping]
Zinc finger and BTB domain-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 155 aa
17.6 kDa 		No 0
ZBTB1-005
ENSP00000450689
ENST00000556965
G3V2I8 [Direct mapping]
Zinc finger and BTB domain-containing protein 1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 130 aa
14.8 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.