We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.
Malignant tissues exhibited weak to moderate cytoplasmic immunoreactivity. A few cases of ovarian cancers showed strong staining. Renal cancers and many cases of lymphomas, urothelial, prostate and endometrial cancers were negative.
Hepatocellular carcinomas exhibited strong cytoplasmic immunoreactivity. Many cases of pancreatic, testicular, endometrial and prostate cancers and a few cases of lung, cervical and stomach cancers showed weak to moderate cytoplasmic staining. The remaining tumors were mainly negative.
GENE INFORMATION
Gene name
WDR60 (HGNC Symbol)
Synonyms
FAP163, FLJ10300
Description
WD repeat domain 60 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD) and may facilitate the formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes including cell cycle progression, signal transduction, apoptosis, and gene regulation. The encoded protein contains four WD repeats and may play a role in the formation of cilia. Mutations in this gene have been associated with short-rib polydactyly and Jeune syndromes. [provided by RefSeq, Mar 2014]
