Tissue expression of NUP214 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	NUP214
Gene description	Nucleoporin 214kDa
Protein class	Cancer-related genes Disease related genes Plasma proteins Potential drug targets Predicted intracellular proteins Predicted secreted proteins Transporters
Predicted localization	Intracellular,Secreted
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	NUP214 (HGNC Symbol)
Synonyms	CAIN, CAN, D9S46E, N214
Description	Nucleoporin 214kDa (HGNC Symbol)
Entrez gene summary	The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome. [provided by RefSeq, Jul 2008]
Chromosome	9
Cytoband	q34.13
Chromosome location (bp)	131125561 - 131234670
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000126883 (version 83.38)
Entrez gene	8021
UniProt	P35658 (UniProt - Evidence at protein level)
neXtProt	NX_P35658
Antibodypedia	NUP214 antibodies

PROTEIN BROWSER

NUP214-001	NUP214-006	NUP214-007	NUP214-009	NUP214-010	NUP214-015	NUP214-018	NUP214-025	NUP214-027	NUP214-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NUP214-001 ENSP00000352400 ENST00000359428	P35658 [Direct mapping] Nuclear pore complex protein Nup214 Show all	Transporters Transporter channels and pores THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0005215 [transporter activity] GO:0005487 [nucleocytoplasmic transporter activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005635 [nuclear envelope] GO:0005643 [nuclear pore] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0005925 [focal adhesion] GO:0005975 [carbohydrate metabolic process] GO:0006406 [mRNA export from nucleus] GO:0006606 [protein import into nucleus] GO:0006611 [protein export from nucleus] GO:0007067 [mitotic nuclear division] GO:0007077 [mitotic nuclear envelope disassembly] GO:0008033 [tRNA processing] GO:0008139 [nuclear localization sequence binding] GO:0008645 [hexose transport] GO:0010467 [gene expression] GO:0010827 [regulation of glucose transport] GO:0015758 [glucose transport] GO:0016032 [viral process] GO:0016925 [protein sumoylation] GO:0019048 [modulation by virus of host morphology or physiology] GO:0019054 [modulation by virus of host process] GO:0019058 [viral life cycle] GO:0019083 [viral transcription] GO:0019221 [cytokine-mediated signaling pathway] GO:0031047 [gene silencing by RNA] GO:0034605 [cellular response to heat] GO:0043231 [intracellular membrane-bounded organelle] GO:0043488 [regulation of mRNA stability] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0044281 [small molecule metabolic process] GO:0051726 [regulation of cell cycle] GO:0055085 [transmembrane transport] GO:1900034 [regulation of cellular response to heat] Show all	2090 aa 213.6 kDa	No	0
NUP214-006 ENSP00000433606 ENST00000476004	H0YDH2 [Direct mapping] Nuclear pore complex protein Nup214 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		145 aa 14.4 kDa	No	0
NUP214-007 ENSP00000435583 ENST00000498010	H0YED3 [Direct mapping] Nuclear pore complex protein Nup214 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		113 aa 12.1 kDa	Yes	0
NUP214-009 ENSP00000436793 ENST00000483497	B7ZAV2 [Direct mapping] Nuclear pore complex protein Nup214; cDNA, FLJ79316, highly similar to Nuclear pore complex protein Nup214 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		916 aa 88 kDa	No	0
NUP214-010 ENSP00000396576 ENST00000411637	P35658 [Direct mapping] Nuclear pore complex protein Nup214 Show all	Transporters Transporter channels and pores THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0005215 [transporter activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005643 [nuclear pore] GO:0005654 [nucleoplasm] GO:0005829 [cytosol] GO:0005925 [focal adhesion] GO:0005975 [carbohydrate metabolic process] GO:0006611 [protein export from nucleus] GO:0007077 [mitotic nuclear envelope disassembly] GO:0008033 [tRNA processing] GO:0008645 [hexose transport] GO:0010467 [gene expression] GO:0010827 [regulation of glucose transport] GO:0015758 [glucose transport] GO:0016032 [viral process] GO:0016925 [protein sumoylation] GO:0019048 [modulation by virus of host morphology or physiology] GO:0019054 [modulation by virus of host process] GO:0019058 [viral life cycle] GO:0019083 [viral transcription] GO:0019221 [cytokine-mediated signaling pathway] GO:0031047 [gene silencing by RNA] GO:0034605 [cellular response to heat] GO:0043231 [intracellular membrane-bounded organelle] GO:0043488 [regulation of mRNA stability] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0044281 [small molecule metabolic process] GO:0055085 [transmembrane transport] GO:1900034 [regulation of cellular response to heat] Show all	2080 aa 212.6 kDa	No	0
NUP214-015 ENSP00000434223 ENST00000530863	H0YDS4 [Direct mapping] Nuclear pore complex protein Nup214 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		187 aa 19.6 kDa	No	0
NUP214-018 ENSP00000435364 ENST00000531600	E9PKD2 [Direct mapping] Nuclear pore complex protein Nup214 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		495 aa 48 kDa	No	0
NUP214-025 ENSP00000435874 ENST00000531584	E9PS86 [Direct mapping] Nuclear pore complex protein Nup214 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		52 aa 6 kDa	No	0
NUP214-027 ENSP00000433654 ENST00000528406	H0YDI2 [Direct mapping] Nuclear pore complex protein Nup214 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		78 aa 7.4 kDa	No	0
NUP214-201 ENSP00000405014 ENST00000451030	A0A0A0MSW3 [Direct mapping] Nuclear pore complex protein Nup214 Show all	Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all		1519 aa 152.6 kDa	No	0