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CTAG2

GENERAL INFORMATION

Gene name

 CTAG2

Gene description

 Cancer/testis antigen 2

Protein class

 Cancer-related genes
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (testis, placenta, heart muscle, fallopian tube, skeletal muscle)
GTEx:Tissue enriched (testis)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in a subset of cells in seminiferous ducts of testis.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Presumed off target binding observed and disregarded.

Reliability score

 Supported based on 1 antibody.
HPA071467
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (testis, placenta, heart muscle, fallopian tube, skeletal muscle)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (testis)

GENE INFORMATION

Gene name

 CTAG2 (HGNC Symbol)

Synonyms

 CAMEL, CT6.2a, CT6.2b, ESO2, LAGE-1, LAGE-1a, LAGE-1b, LAGE1, MGC138724, MGC3803

Description

 Cancer/testis antigen 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes an autoimmunogenic tumor antigen that belongs to the ESO/LAGE family of cancer-testis antigens. This protein is expressed in a wide array of cancers including melanoma, breast cancer, bladder cancer and prostate cancer. This protein is also expressed in normal testis tissue. An alternative open reading frame product of this gene has been described in PMID:10399963. This alternate protein, termed CAMEL, is a tumor antigen that is recognized by melanoma-specific cytotoxic T-lymphocytes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

Chromosome

 X

Cytoband

 q28

Chromosome location (bp)

 154651972 - 154653579

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000126890 (version 83.38)

Entrez gene

 30848

UniProt

 O75638 (UniProt - Evidence at protein level)

neXtProt

 NX_O75638

Antibodypedia

 CTAG2 antibodies

PROTEIN BROWSER
CTAG2-001
CTAG2-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CTAG2-001
ENSP00000247306
ENST00000247306
O75638 [Direct mapping]
Cancer/testis antigen 2
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Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
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GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0008150 [biological_process]
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 210 aa
21.1 kDa 		No 0
CTAG2-002
ENSP00000358598
ENST00000369585
O75638 [Direct mapping]
Cancer/testis antigen 2
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   Phobius predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003674 [molecular_function]
GO:0005515 [protein binding]
GO:0005813 [centrosome]
GO:0008150 [biological_process]
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 180 aa
18.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.