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Malignant cells exhibited weak to moderate cytoplasmic immunoreactivity. Malignant lymphomas and several cases of lung, cervical, prostate, gastric and renal cancers were negative.
Most malignancies were negative. Several pancreatic and thyroid cancer as well as a few cases of liver cancers displayed moderate to strong cytoplasmic immunoreactivity.
This gene encodes a member of the ALEX family of proteins and may play a role in tumor suppression. The encoded protein contains a potential N-terminal transmembrane domain and two Armadillo (arm) repeats. Other proteins containing the arm repeat are involved in development, maintenance of tissue integrity, and tumorigenesis. This gene is closely localized with other family members, including ALEX2 and ALEX3, on the X chromosome. [provided by RefSeq, Jul 2008]
