Expression of CANX in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Calnexin

Protein class

Cancer-related genes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA009433	HPA009696	CAB004738

GENE INFORMATION
Gene name	CANX (HGNC Symbol)
Synonyms	CNX, IP90, P90
Description	Calnexin (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the calnexin family of molecular chaperones. The encoded protein is a calcium-binding, endoplasmic reticulum (ER)-associated protein that interacts transiently with newly synthesized N-linked glycoproteins, facilitating protein folding and assembly. It may also play a central role in the quality control of protein folding by retaining incorrectly folded protein subunits within the ER for degradation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q35.3
Chromosome location (bp)	179678628 - 179730925
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000127022 (version 83.38)
Entrez gene	821
UniProt	P27824 (UniProt - Evidence at protein level)
neXtProt	NX_P27824
Antibodypedia	CANX antibodies

PROTEIN BROWSER

CANX-001	CANX-002	CANX-003	CANX-005	CANX-006	CANX-007	CANX-008	CANX-009	CANX-010	CANX-014	CANX-017	CANX-018	CANX-021

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CANX-001 ENSP00000247461 ENST00000247461	P27824 [Direct mapping] Calnexin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001948 [glycoprotein binding] GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005737 [cytoplasm] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0005789 [endoplasmic reticulum membrane] GO:0005790 [smooth endoplasmic reticulum] GO:0005791 [rough endoplasmic reticulum] GO:0005840 [ribosome] GO:0006457 [protein folding] GO:0007568 [aging] GO:0009306 [protein secretion] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0030246 [carbohydrate binding] GO:0030424 [axon] GO:0032839 [dendrite cytoplasm] GO:0034185 [apolipoprotein binding] GO:0034975 [protein folding in endoplasmic reticulum] GO:0035255 [ionotropic glutamate receptor binding] GO:0042470 [melanosome] GO:0043025 [neuronal cell body] GO:0043197 [dendritic spine] GO:0043209 [myelin sheath] GO:0043234 [protein complex] GO:0043687 [post-translational protein modification] GO:0044233 [ER-mitochondrion membrane contact site] GO:0044267 [cellular protein metabolic process] GO:0044822 [poly(A) RNA binding] GO:0048488 [synaptic vesicle endocytosis] GO:0051082 [unfolded protein binding] GO:0061077 [chaperone-mediated protein folding] GO:0070062 [extracellular exosome] GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane] GO:0072583 [clathrin-mediated endocytosis] Show all	592 aa 67.6 kDa	Yes	1
CANX-002 ENSP00000424063 ENST00000504734	P27824 [Direct mapping] Calnexin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0009306 [protein secretion] GO:0016020 [membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0030246 [carbohydrate binding] GO:0034975 [protein folding in endoplasmic reticulum] GO:0042470 [melanosome] GO:0043687 [post-translational protein modification] GO:0044233 [ER-mitochondrion membrane contact site] GO:0044267 [cellular protein metabolic process] GO:0044822 [poly(A) RNA binding] GO:0048488 [synaptic vesicle endocytosis] GO:0051082 [unfolded protein binding] GO:0070062 [extracellular exosome] GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane] GO:0072583 [clathrin-mediated endocytosis] Show all	592 aa 67.6 kDa	Yes	1
CANX-003 ENSP00000421107 ENST00000502673	D6RGY2 [Direct mapping] Calnexin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0006457 [protein folding] GO:0051082 [unfolded protein binding] Show all	308 aa 35.2 kDa	Yes	0
CANX-005 ENSP00000391646 ENST00000452673	P27824 [Direct mapping] Calnexin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002474 [antigen processing and presentation of peptide antigen via MHC class I] GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005783 [endoplasmic reticulum] GO:0005788 [endoplasmic reticulum lumen] GO:0005789 [endoplasmic reticulum membrane] GO:0006457 [protein folding] GO:0009306 [protein secretion] GO:0016020 [membrane] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0019886 [antigen processing and presentation of exogenous peptide antigen via MHC class II] GO:0030246 [carbohydrate binding] GO:0034975 [protein folding in endoplasmic reticulum] GO:0042470 [melanosome] GO:0043687 [post-translational protein modification] GO:0044233 [ER-mitochondrion membrane contact site] GO:0044267 [cellular protein metabolic process] GO:0044822 [poly(A) RNA binding] GO:0048488 [synaptic vesicle endocytosis] GO:0051082 [unfolded protein binding] GO:0070062 [extracellular exosome] GO:0071556 [integral component of lumenal side of endoplasmic reticulum membrane] GO:0072583 [clathrin-mediated endocytosis] Show all	592 aa 67.6 kDa	Yes	1
CANX-006 ENSP00000424745 ENST00000502296	D6RAU8 [Direct mapping] Calnexin Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005783 [endoplasmic reticulum] GO:0006457 [protein folding] GO:0051082 [unfolded protein binding] Show all	134 aa 14.8 kDa	Yes	0
CANX-007 ENSP00000425246 ENST00000502498	D6RDP7 [Direct mapping] Calnexin Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005783 [endoplasmic reticulum] GO:0006457 [protein folding] GO:0051082 [unfolded protein binding] Show all	168 aa 18.7 kDa	Yes	0
CANX-008 ENSP00000426052 ENST00000507307	D6RHJ3 [Direct mapping] Calnexin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005783 [endoplasmic reticulum] GO:0006457 [protein folding] GO:0051082 [unfolded protein binding] Show all	79 aa 8.6 kDa	Yes	0
CANX-009 ENSP00000421813 ENST00000513246	D6RAQ8 [Direct mapping] Calnexin Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005783 [endoplasmic reticulum] GO:0006457 [protein folding] GO:0051082 [unfolded protein binding] Show all	107 aa 11.9 kDa	Yes	0
CANX-010 ENSP00000421434 ENST00000509563	D6RFW4 [Direct mapping] Calnexin Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		32 aa 3.6 kDa	Yes	0
CANX-014 ENSP00000424140 ENST00000508787	H0Y9H1 [Direct mapping] Calnexin Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005783 [endoplasmic reticulum] GO:0006457 [protein folding] GO:0051082 [unfolded protein binding] Show all	190 aa 21.4 kDa	No	0
CANX-017 ENSP00000426555 ENST00000506654	D6RFL1 [Direct mapping] Calnexin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005783 [endoplasmic reticulum] GO:0006457 [protein folding] GO:0051082 [unfolded protein binding] Show all	131 aa 15.2 kDa	No	0
CANX-018 ENSP00000424740 ENST00000510810	H0Y9Q7 [Direct mapping] Calnexin Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005783 [endoplasmic reticulum] GO:0006457 [protein folding] GO:0051082 [unfolded protein binding] Show all	170 aa 18.7 kDa	No	0
CANX-021 ENSP00000424341 ENST00000514383	D6RB85 [Direct mapping] Calnexin Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005783 [endoplasmic reticulum] GO:0006457 [protein folding] GO:0051082 [unfolded protein binding] Show all	144 aa 16 kDa	Yes	0