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Several colorectal, stomach, pancreatic, prostate cancers, cholangiocarcinomas along with occasional cases of ovarian, lung and cervical cancers displayed moderate to strong strong membranous staining with additional cytoplasmic positivity in few cases. Other cancer tissues were in general weakly stained or negative.
A few cases of stomach cancers displayed strong membranous and cytoplasmic immunoreactivity while a few cases of colorectal cancers were moderately stained. Remaining malignant cells were negative.
GENE INFORMATION
Gene name
TSPAN8 (HGNC Symbol)
Synonyms
CO-029, TM4SF3
Description
Tetraspanin 8 (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]