Expression of BEST3 in cancer - Summary

CANCER ATLAS

Gene description

Bestrophin 3

Protein class

Predicted intracellular proteins, Predicted membrane proteins

Protein evidence

Evidence at transcript level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA054582

GENE INFORMATION
Gene name	BEST3 (HGNC Symbol)
Synonyms	MGC13168, MGC40411, VMD2L3
Description	Bestrophin 3 (HGNC Symbol)
Entrez gene summary	BEST3 belongs to the bestrophin family of anion channels, which includes BEST1 (MIM 607854), the gene mutant in vitelliform macular dystrophy (VMD; MIM 153700), and 2 other BEST1-like genes, BEST2 (MIM 607335) and BEST4 (MIM 607336). Bestrophins are transmembrane (TM) proteins that share a homology region containing a high content of aromatic residues, including an invariant arg-phe-pro (RFP) motif. The bestrophin genes share a conserved gene structure, with almost identical sizes of the 8 RFP-TM domain-encoding exons and highly conserved exon-intron boundaries. Each of the 4 bestrophin genes has a unique 3-prime end of variable length (Stohr et al., 2002 [PubMed 12032738]; Tsunenari et al., 2003 [PubMed 12907679]).[supplied by OMIM, Mar 2008]
Chromosome	12
Cytoband	q15
Chromosome location (bp)	69643360 - 69699476
Protein evidence	Evidence at transcript level (all genes)
Ensembl	ENSG00000127325 (version 83.38)
Entrez gene	144453
UniProt	Q8N1M1 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8N1M1
Antibodypedia	BEST3 antibodies

PROTEIN BROWSER

BEST3-001	BEST3-002	BEST3-003	BEST3-004	BEST3-008	BEST3-009	BEST3-010	BEST3-012	BEST3-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BEST3-001 ENSP00000332413 ENST00000330891	Q8N1M1 [Direct mapping] Bestrophin-3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0003674 [molecular_function] GO:0005254 [chloride channel activity] GO:0005887 [integral component of plasma membrane] GO:0008150 [biological_process] GO:0015698 [inorganic anion transport] GO:0034707 [chloride channel complex] GO:0043271 [negative regulation of ion transport] GO:1902476 [chloride transmembrane transport] Show all	668 aa 76.1 kDa	No	4
BEST3-002 ENSP00000433213 ENST00000488961	Q8N1M1 [Direct mapping] Bestrophin-3 Show all	Predicted intracellular proteins Show all	GO:0003674 [molecular_function] GO:0005254 [chloride channel activity] GO:0005887 [integral component of plasma membrane] GO:0008150 [biological_process] GO:0034707 [chloride channel complex] GO:1902476 [chloride transmembrane transport] Show all	455 aa 51 kDa	No	0
BEST3-003 ENSP00000434713 ENST00000476098	E9PNM2 [Direct mapping] Bestrophin-3 Show all	Predicted intracellular proteins Show all		197 aa 22.8 kDa	No	0
BEST3-004 ENSP00000266661 ENST00000266661	Q8N1M1 [Direct mapping] Bestrophin-3 Show all	Predicted intracellular proteins Show all	GO:0003674 [molecular_function] GO:0005254 [chloride channel activity] GO:0005887 [integral component of plasma membrane] GO:0008150 [biological_process] GO:0034707 [chloride channel complex] GO:1902476 [chloride transmembrane transport] Show all	72 aa 8.3 kDa	No	0
BEST3-008 ENSP00000329064 ENST00000331471	Q8N1M1 [Direct mapping] Bestrophin-3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Show all	GO:0003674 [molecular_function] GO:0005254 [chloride channel activity] GO:0005887 [integral component of plasma membrane] GO:0008150 [biological_process] GO:0034707 [chloride channel complex] GO:1902476 [chloride transmembrane transport] Show all	398 aa 46.6 kDa	No	4
BEST3-009 ENSP00000449548 ENST00000553096	Q8N1M1 [Direct mapping] Bestrophin-3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0003674 [molecular_function] GO:0005254 [chloride channel activity] GO:0005887 [integral component of plasma membrane] GO:0008150 [biological_process] GO:0034707 [chloride channel complex] GO:1902476 [chloride transmembrane transport] Show all	562 aa 63.4 kDa	No	2
BEST3-010 ENSP00000449377 ENST00000551160	Q8N1M1 [Direct mapping] Bestrophin-3 Show all	Predicted intracellular proteins Show all	GO:0003674 [molecular_function] GO:0005254 [chloride channel activity] GO:0005887 [integral component of plasma membrane] GO:0008150 [biological_process] GO:0034707 [chloride channel complex] GO:1902476 [chloride transmembrane transport] Show all	72 aa 8.3 kDa	No	0
BEST3-012 ENSP00000446575 ENST00000548658	F8VR37 [Direct mapping] Bestrophin-3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0016021 [integral component of membrane] Show all	142 aa 17 kDa	No	1
BEST3-013 ENSP00000447689 ENST00000552295	F8VZR0 [Direct mapping] Bestrophin-3 Show all	Predicted intracellular proteins Show all		161 aa 18.9 kDa	No	0