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Peptidyl-prolyl cis/trans isomerases (PPIases) catalyze the cis/trans isomerization of peptidyl-prolyl peptide bonds. This gene encodes one of the PPIases, which specifically binds to phosphorylated ser/thr-pro motifs to catalytically regulate the post-phosphorylation conformation of its substrates. The conformational regulation catalyzed by this PPIase has a profound impact on key proteins involved in the regulation of cell growth, genotoxic and other stress responses, the immune response, induction and maintenance of pluripotency, germ cell development, neuronal differentiation, and survival. This enzyme also plays a key role in the pathogenesis of Alzheimer's disease and many cancers. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011]
Enzymes ENZYME proteins Isomerase Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
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GO:0000413 [protein peptidyl-prolyl isomerization] GO:0001934 [positive regulation of protein phosphorylation] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005829 [cytosol] GO:0007049 [cell cycle] GO:0007088 [regulation of mitotic nuclear division] GO:0016607 [nuclear speck] GO:0016853 [isomerase activity] GO:0019221 [cytokine-mediated signaling pathway] GO:0030496 [midbody] GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] GO:0031434 [mitogen-activated protein kinase kinase binding] GO:0032465 [regulation of cytokinesis] GO:0032480 [negative regulation of type I interferon production] GO:0032794 [GTPase activating protein binding] GO:0035307 [positive regulation of protein dephosphorylation] GO:0043005 [neuron projection] GO:0043524 [negative regulation of neuron apoptotic process] GO:0043525 [positive regulation of neuron apoptotic process] GO:0043547 [positive regulation of GTPase activity] GO:0045087 [innate immune response] GO:0050815 [phosphoserine binding] GO:0050816 [phosphothreonine binding] GO:0051443 [positive regulation of ubiquitin-protein transferase activity] GO:0060393 [regulation of pathway-restricted SMAD protein phosphorylation] GO:0061051 [positive regulation of cell growth involved in cardiac muscle cell development] GO:0070373 [negative regulation of ERK1 and ERK2 cascade] GO:2000146 [negative regulation of cell motility]
Enzymes ENZYME proteins Isomerase Predicted intracellular proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000413 [protein peptidyl-prolyl isomerization] GO:0001934 [positive regulation of protein phosphorylation] GO:0003755 [peptidyl-prolyl cis-trans isomerase activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0007049 [cell cycle] GO:0007088 [regulation of mitotic nuclear division] GO:0016607 [nuclear speck] GO:0016853 [isomerase activity] GO:0019221 [cytokine-mediated signaling pathway] GO:0030496 [midbody] GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway] GO:0031434 [mitogen-activated protein kinase kinase binding] GO:0032465 [regulation of cytokinesis] GO:0032480 [negative regulation of type I interferon production] GO:0032794 [GTPase activating protein binding] GO:0043547 [positive regulation of GTPase activity] GO:0045087 [innate immune response] GO:0050815 [phosphoserine binding] GO:0050816 [phosphothreonine binding] GO:0051443 [positive regulation of ubiquitin-protein transferase activity] GO:0060393 [regulation of pathway-restricted SMAD protein phosphorylation] GO:0070373 [negative regulation of ERK1 and ERK2 cascade] GO:2000146 [negative regulation of cell motility]
