Cell atlas - EMC1 - The Human Protein Atlas

GENERAL INFORMATION
Gene name	EMC1
Gene description	ER membrane protein complex subunit 1
Protein class	Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the microtubules. In addition localized to the cytokinetic bridge.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Microtubules (approved)
Additional location	In addition localized to the Cytokinetic bridge (approved)
Single-cell variation	Single-cell variation in protein expression observed.
Cell cycle dependency	Cell cycle dependent expression determined by biological definition
Mouse	Localized to the Microtubules in mouse cells.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA048904
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ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the microtubules. In addition localized to the cytokinetic bridge.

Main location

Microtubules (approved)

Additional location

Cytokinetic bridge (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
HPA048904	A-431	Vesicles
HPA048904	A-431	Microtubules
HPA048904	PC-3	Microtubules
HPA048904	U-2 OS	Microtubules
HPA048904	U-2 OS	Cytokinetic bridge	Intensity	Intensity

CELL CYCLE
Summary	Expression has cell cycle dependency according to biological definition
Intensity variation	Cytokinetic bridge

MOUSE CELLS

Main location

Microtubules

Mouse gene

ENSMUSG00000078517 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA048904	NIH 3T3	Microtubules

GENE INFORMATION
Gene name	EMC1 (HGNC Symbol)
Synonyms	KIAA0090
Description	ER membrane protein complex subunit 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a single-pass type I transmembrane protein, which is a subunit of the endoplasmic reticulum membrane protein complex (EMC). Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2012]
Chromosome	1
Cytoband	p36.13
Chromosome location (bp)	19215664 - 19251552
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000127463 (version 83.38)
Entrez gene	23065
UniProt	Q8N766 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N766
Antibodypedia	EMC1 antibodies

PROTEIN BROWSER

EMC1-002	EMC1-003	EMC1-006	EMC1-009	EMC1-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EMC1-002 ENSP00000364354 ENST00000375208	Q8N766 [Direct mapping] ER membrane protein complex subunit 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0034975 [protein folding in endoplasmic reticulum] GO:0072546 [ER membrane protein complex] Show all	971 aa 109.4 kDa	Yes	1
EMC1-003 ENSP00000420608 ENST00000477853	Q8N766 [Direct mapping] ER membrane protein complex subunit 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] GO:0034975 [protein folding in endoplasmic reticulum] GO:0072546 [ER membrane protein complex] Show all	993 aa 111.8 kDa	Yes	1
EMC1-006 ENSP00000364329 ENST00000356068	Q5TG59 [Direct mapping] ER membrane protein complex subunit 1 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0072546 [ER membrane protein complex] Show all	75 aa 8.4 kDa	Yes	0
EMC1-009 ENSP00000364345 ENST00000375199	Q8N766 [Direct mapping] ER membrane protein complex subunit 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] GO:0034975 [protein folding in endoplasmic reticulum] GO:0072546 [ER membrane protein complex] Show all	992 aa 111.6 kDa	Yes	1
EMC1-013 ENSP00000419345 ENST00000486405	H7C5A2 [Direct mapping] ER membrane protein complex subunit 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0072546 [ER membrane protein complex] Show all	178 aa 20.5 kDa	No	0