Cell atlas - EPS15L1 - The Human Protein Atlas

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EPS15L1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Vesicles

Human cell
	Vesicles

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GENERAL INFORMATION
Gene name	EPS15L1
Gene description	Epidermal growth factor receptor pathway substrate 15-like 1
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to vesicles.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Vesicles (approved)
Mouse	Localized to the Vesicles, Microtubule organizing center in mouse cells.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA055309
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to vesicles.

Main location

Vesicles (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA055309	A-431	No staining
	HPA055309	MCF7	Vesicles
	HPA055309	U-2 OS	Vesicles

MOUSE CELLS

Main location

Vesicles, Microtubule organizing center

Additional location

Nucleoplasm

Mouse gene

ENSMUSG00000006276 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA055309	NIH 3T3	Nucleoplasm
			Vesicles
			Microtubule organizing center

GENE INFORMATION
Gene name	EPS15L1 (HGNC Symbol)
Synonyms	eps15R
Description	Epidermal growth factor receptor pathway substrate 15-like 1 (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	p13.11
Chromosome location (bp)	16355239 - 16472085
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000127527 (version 83.38)
Entrez gene	58513
UniProt	Q9UBC2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UBC2
Antibodypedia	EPS15L1 antibodies

PROTEIN BROWSER

EPS15L1-001	EPS15L1-002	EPS15L1-004	EPS15L1-006	EPS15L1-007	EPS15L1-008	EPS15L1-012	EPS15L1-015	EPS15L1-016

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EPS15L1-001 ENSP00000393313 ENST00000455140	Q9UBC2 [Direct mapping] Epidermal growth factor receptor substrate 15-like 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0006897 [endocytosis] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0016020 [membrane] GO:0030132 [clathrin coat of coated pit] GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway] Show all	910 aa 99.6 kDa	No	0
EPS15L1-002 ENSP00000440103 ENST00000535753	Q9UBC2 [Direct mapping] Epidermal growth factor receptor substrate 15-like 1 A0A024R7G6 [Target identity:100%; Query identity:100%] Epidermal growth factor receptor pathway substrate 15-like 1, isoform CRA_a Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0006897 [endocytosis] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0016020 [membrane] GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway] Show all	754 aa 83.2 kDa	No	0
EPS15L1-004 ENSP00000471662 ENST00000594975	M0R165 [Direct mapping] Epidermal growth factor receptor substrate 15-like 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	756 aa 83.5 kDa	No	0
EPS15L1-006 ENSP00000248070 ENST00000248070	Q9UBC2 [Direct mapping] Epidermal growth factor receptor substrate 15-like 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0006897 [endocytosis] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0016020 [membrane] GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway] Show all	864 aa 94.3 kDa	No	0
EPS15L1-007 ENSP00000472267 ENST00000597937	Q9UBC2 [Direct mapping] Epidermal growth factor receptor substrate 15-like 1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0006897 [endocytosis] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0016020 [membrane] GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway] Show all	601 aa 66.5 kDa	No	0
EPS15L1-008 ENSP00000472771 ENST00000602009	M0R2S2 [Direct mapping] Epidermal growth factor receptor substrate 15-like 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	447 aa 49.9 kDa	No	0
EPS15L1-012 ENSP00000468866 ENST00000602151	M0QX30 [Direct mapping] Epidermal growth factor receptor substrate 15-like 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	90 aa 9.4 kDa	No	0
EPS15L1-015 ENSP00000473242 ENST00000599790	M0R3I1 [Direct mapping] Epidermal growth factor receptor substrate 15-like 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		213 aa 23.2 kDa	No	0
EPS15L1-016 ENSP00000469495 ENST00000594851	M0QY01 [Direct mapping] Epidermal growth factor receptor substrate 15-like 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		71 aa 7.9 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.