Tissue expression of EPS15L1 - Summary - The Human Protein Atlas

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EPS15L1

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	EPS15L1
Gene description	Epidermal growth factor receptor pathway substrate 15-like 1
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Ubiquitous cytoplasmic expression.

DATA RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA019237
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	EPS15L1 (HGNC Symbol)
Synonyms	eps15R
Description	Epidermal growth factor receptor pathway substrate 15-like 1 (HGNC Symbol)
Entrez gene summary
Chromosome	19
Cytoband	p13.11
Chromosome location (bp)	16355239 - 16472085
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000127527 (version 83.38)
Entrez gene	58513
UniProt	Q9UBC2 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UBC2
Antibodypedia	EPS15L1 antibodies

PROTEIN BROWSER

EPS15L1-001	EPS15L1-002	EPS15L1-004	EPS15L1-006	EPS15L1-007	EPS15L1-008	EPS15L1-012	EPS15L1-015	EPS15L1-016

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EPS15L1-001 ENSP00000393313 ENST00000455140	Q9UBC2 [Direct mapping] Epidermal growth factor receptor substrate 15-like 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0006897 [endocytosis] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0016020 [membrane] GO:0030132 [clathrin coat of coated pit] GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway] Show all	910 aa 99.6 kDa	No	0
EPS15L1-002 ENSP00000440103 ENST00000535753	Q9UBC2 [Direct mapping] Epidermal growth factor receptor substrate 15-like 1 A0A024R7G6 [Target identity:100%; Query identity:100%] Epidermal growth factor receptor pathway substrate 15-like 1, isoform CRA_a Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0006897 [endocytosis] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0016020 [membrane] GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway] Show all	754 aa 83.2 kDa	No	0
EPS15L1-004 ENSP00000471662 ENST00000594975	M0R165 [Direct mapping] Epidermal growth factor receptor substrate 15-like 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	756 aa 83.5 kDa	No	0
EPS15L1-006 ENSP00000248070 ENST00000248070	Q9UBC2 [Direct mapping] Epidermal growth factor receptor substrate 15-like 1 Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0006897 [endocytosis] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0016020 [membrane] GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway] Show all	864 aa 94.3 kDa	No	0
EPS15L1-007 ENSP00000472267 ENST00000597937	Q9UBC2 [Direct mapping] Epidermal growth factor receptor substrate 15-like 1 Show all	Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005886 [plasma membrane] GO:0006897 [endocytosis] GO:0007173 [epidermal growth factor receptor signaling pathway] GO:0016020 [membrane] GO:0042059 [negative regulation of epidermal growth factor receptor signaling pathway] Show all	601 aa 66.5 kDa	No	0
EPS15L1-008 ENSP00000472771 ENST00000602009	M0R2S2 [Direct mapping] Epidermal growth factor receptor substrate 15-like 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005509 [calcium ion binding] GO:0005515 [protein binding] Show all	447 aa 49.9 kDa	No	0
EPS15L1-012 ENSP00000468866 ENST00000602151	M0QX30 [Direct mapping] Epidermal growth factor receptor substrate 15-like 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	90 aa 9.4 kDa	No	0
EPS15L1-015 ENSP00000473242 ENST00000599790	M0R3I1 [Direct mapping] Epidermal growth factor receptor substrate 15-like 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		213 aa 23.2 kDa	No	0
EPS15L1-016 ENSP00000469495 ENST00000594851	M0QY01 [Direct mapping] Epidermal growth factor receptor substrate 15-like 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		71 aa 7.9 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.