Expression of GFER in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Growth factor, augmenter of liver regeneration

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA041227

GENE INFORMATION
Gene name	GFER (HGNC Symbol)
Synonyms	ALR, ERV1, HERV1, HPO1, HPO2, HSS
Description	Growth factor, augmenter of liver regeneration (HGNC Symbol)
Entrez gene summary	The hepatotrophic factor designated augmenter of liver regeneration (ALR) is thought to be one of the factors responsible for the extraordinary regenerative capacity of mammalian liver. It has also been called hepatic regenerative stimulation substance (HSS). The gene resides on chromosome 16 in the interval containing the locus for polycystic kidney disease (PKD1). The putative gene product is 42% similar to the scERV1 protein of yeast. The yeast scERV1 gene had been found to be essential for oxidative phosphorylation, the maintenance of mitochondrial genomes, and the cell division cycle. The human gene is both the structural and functional homolog of the yeast scERV1 gene. [provided by RefSeq, Jul 2008]
Chromosome	16
Cytoband	p13.3
Chromosome location (bp)	1984207 - 1987749
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000127554 (version 83.38)
Entrez gene	2671
UniProt	P55789 (UniProt - Evidence at protein level)
neXtProt	NX_P55789
Antibodypedia	GFER antibodies

PROTEIN BROWSER

GFER-001	GFER-002	GFER-003	GFER-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GFER-001 ENSP00000248114 ENST00000248114	P55789 [Direct mapping] FAD-linked sulfhydryl oxidase ALR Show all	Enzymes ENZYME proteins Oxidoreductases Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005758 [mitochondrial intermembrane space] GO:0006626 [protein targeting to mitochondrion] GO:0008083 [growth factor activity] GO:0015035 [protein disulfide oxidoreductase activity] GO:0016972 [thiol oxidase activity] GO:0044267 [cellular protein metabolic process] GO:0050660 [flavin adenine dinucleotide binding] GO:0055114 [oxidation-reduction process] Show all	205 aa 23.4 kDa	No	0
GFER-002 ENSP00000455885 ENST00000567719	H3BQQ4 [Direct mapping] Sulfhydryl oxidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0016972 [thiol oxidase activity] GO:0055114 [oxidation-reduction process] Show all	130 aa 15.4 kDa	No	0
GFER-003 ENSP00000456432 ENST00000569451	H3BRW3 [Direct mapping] FAD-linked sulfhydryl oxidase ALR Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		109 aa 11.7 kDa	No	0
GFER-004 ENSP00000456189 ENST00000561710	H3BRD2 [Direct mapping] Sulfhydryl oxidase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016972 [thiol oxidase activity] GO:0055114 [oxidation-reduction process] Show all	139 aa 15.8 kDa	No	0