Cell atlas - CHTF18 - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

CHTF18

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS MOUSE CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Nucleoplasm

Human cell
	Cytosol
	Nucleoplasm

Please wait until image is loaded before changing channels

GENERAL INFORMATION
Gene name	CHTF18
Gene description	Chromosome transmission fidelity factor 18
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION
Summary	Mainly localized to the nucleoplasm. In addition localized to the cytosol.
RNA cell category	Cell line enhanced (BEWO)
Protein evidence	Evidence at protein level
Main location	Localized to the Nucleoplasm (validated)
Additional location	In addition localized to the Cytosol (approved)
Mouse	Localized to the Nucleoplasm in mouse cells.

DATA RELIABILITY
Reliability score	Validated based on 2 antibodies. HPA040976 , HPA056209
	SHOW MORE

ASSAYS

RNA expression

Human cells

Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (BEWO) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Mainly localized to the nucleoplasm. In addition localized to the cytosol.

Main location

Nucleoplasm (validated)

Additional location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Antibody	Cell line	Location
HPA040976	HeLa	Nucleoplasm
HPA040976	HeLa	Cytosol
HPA040976	MCF7	Nucleoplasm
HPA040976	U-2 OS	Nucleoplasm
HPA040976	U-2 OS	Cytosol
HPA056209	HeLa	Nucleoplasm
HPA056209	MCF7	Nucleoplasm
HPA056209	U-2 OS	Nucleoplasm

MOUSE CELLS

Main location

Nucleoplasm

Mouse gene

ENSMUSG00000019214 (version 83)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location
	HPA056209	NIH 3T3	Nucleoplasm

GENE INFORMATION
Gene name	CHTF18 (HGNC Symbol)
Synonyms	C16orf41, C321D2.4, CHL12, Ctf18
Description	Chromosome transmission fidelity factor 18 (HGNC Symbol)
Entrez gene summary	CHTF18, CHTF8 (MIM 613202), and DCC1 (DSCC1; MIM 613203) are components of an alternative replication factor C (RFC) (see MIM 600404) complex that loads PCNA (MIM 176740) onto DNA during S phase of the cell cycle (Merkle et al., 2003 [PubMed 12766176]; Bermudez et al., 2003 [PubMed 12930902]).[supplied by OMIM, Dec 2009]
Chromosome	16
Cytoband	p13.3
Chromosome location (bp)	788046 - 800737
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000127586 (version 83.38)
Entrez gene	63922
UniProt	Q8WVB6 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WVB6
Antibodypedia	CHTF18 antibodies

PROTEIN BROWSER

CHTF18-001	CHTF18-006	CHTF18-008	CHTF18-201	CHTF18-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CHTF18-001 ENSP00000262315 ENST00000262315	Q8WVB6 [Direct mapping] Chromosome transmission fidelity protein 18 homolog Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006260 [DNA replication] GO:0007049 [cell cycle] GO:0016020 [membrane] Show all	975 aa 107.4 kDa	No	0
CHTF18-006 ENSP00000406252 ENST00000455171	Q8WVB6 [Direct mapping] Chromosome transmission fidelity protein 18 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0006260 [DNA replication] GO:0007049 [cell cycle] GO:0016020 [membrane] Show all	1003 aa 110.2 kDa	No	0
CHTF18-008 ENSP00000412015 ENST00000426047	H0Y7D3 [Direct mapping] Chromosome transmission fidelity protein 18 homolog Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		264 aa 28.9 kDa	No	0
CHTF18-201 ENSP00000313029 ENST00000317063	E7EXA6 [Direct mapping] Chromosome transmission fidelity protein 18 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] Show all	975 aa 107.4 kDa	No	0
CHTF18-202 ENSP00000486314 ENST00000631357	A0A0D9SF58 [Direct mapping] Chromosome transmission fidelity protein 18 homolog Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] Show all	1184 aa 129.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.