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GNG13

GENERAL INFORMATION

Gene name

 GNG13

Gene description

 Guanine nucleotide binding protein (G protein), gamma 13

Protein class

 Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (cerebral cortex, small intestine, duodenum)
GTEx:Group enriched (cerebellum, cerebral cortex)
FANTOM5:Group enriched (cerebellum, retina)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in Purkinje cells of cerebellum, including a subset of cells in gastrointestinal tract.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data. External characterization data supports antibody staining.

Reliability score

 Approved based on 1 antibody.
HPA046272
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Cerebellum

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (cerebral cortex, small intestine, duodenum)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebellum, cerebral cortex)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (cerebellum, retina)

GENE INFORMATION

Gene name

 GNG13 (HGNC Symbol)

Synonyms

 G(gamma)13, h2-35

Description

 Guanine nucleotide binding protein (G protein), gamma 13 (HGNC Symbol)

Entrez gene summary

 Heterotrimeric G proteins, which consist of alpha (see MIM 139320), beta (see MIM 139380), and gamma subunits, function as signal transducers for the 7-transmembrane-helix G protein-coupled receptors. GNG13 is a gamma subunit that is expressed in taste, retinal, and neuronal tissues and plays a key role in taste transduction (Li et al., 2006 [PubMed 16473877]).[supplied by OMIM, Oct 2009]

Chromosome

 16

Cytoband

 p13.3

Chromosome location (bp)

 798041 - 800733

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000127588 (version 83.38)

Entrez gene

 51764

UniProt

 Q9P2W3 (UniProt - Inferred from homology)

neXtProt

 NX_Q9P2W3

Antibodypedia

 GNG13 antibodies

PROTEIN BROWSER
GNG13-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GNG13-001
ENSP00000248150
ENST00000248150
Q9P2W3 [Direct mapping]
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-13
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Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
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GO:0004871 [signal transducer activity]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0006112 [energy reserve metabolic process]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007200 [phospholipase C-activating G-protein coupled receptor signaling pathway]
GO:0030425 [dendrite]
GO:0031681 [G-protein beta-subunit binding]
GO:0044281 [small molecule metabolic process]
GO:0050909 [sensory perception of taste]
GO:0071377 [cellular response to glucagon stimulus]
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 67 aa
7.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.