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MACF1

GENERAL INFORMATION

Gene name

 MACF1

Gene description

 Microtubule-actin crosslinking factor 1

Protein class

 Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 17
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Granular cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 2 antibodies.
HPA013713 , HPA068064
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MACF1 (HGNC Symbol)

Synonyms

 ABP620, ACF7, FLJ45612, FLJ46776, KIAA0465, KIAA1251, MACF

Description

 Microtubule-actin crosslinking factor 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a large protein containing numerous spectrin and leucine-rich repeat (LRR) domains. The encoded protein is a member of a family of proteins that form bridges between different cytoskeletal elements. This protein facilitates actin-microtubule interactions at the cell periphery and couples the microtubule network to cellular junctions. Alternative splicing results in multiple transcript variants, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, May 2013]

Chromosome

 1

Cytoband

 p34.3

Chromosome location (bp)

 39081316 - 39487177

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000127603 (version 83.38)

Entrez gene

 23499

UniProt

 Q9UPN3 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UPN3

Antibodypedia

 MACF1 antibodies

PROTEIN BROWSER
«
MACF1-001
MACF1-003
MACF1-005
MACF1-007
MACF1-010
MACF1-011
MACF1-012
MACF1-016
MACF1-024
MACF1-025
MACF1-028
MACF1-029
MACF1-030
MACF1-031
MACF1-032
MACF1-033
MACF1-034
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MACF1-001
ENSP00000354573
ENST00000361689
Q9UPN3 [Direct mapping]
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001707 [mesoderm formation]
GO:0003779 [actin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0006620 [posttranslational protein targeting to membrane]
GO:0007050 [cell cycle arrest]
GO:0007163 [establishment or maintenance of cell polarity]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0010632 [regulation of epithelial cell migration]
GO:0015629 [actin cytoskeleton]
GO:0015630 [microtubule cytoskeleton]
GO:0016055 [Wnt signaling pathway]
GO:0016887 [ATPase activity]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0032587 [ruffle membrane]
GO:0032886 [regulation of microtubule-based process]
GO:0042060 [wound healing]
GO:0043001 [Golgi to plasma membrane protein transport]
GO:0044822 [poly(A) RNA binding]
GO:0045773 [positive regulation of axon extension]
GO:0051015 [actin filament binding]
GO:0051893 [regulation of focal adhesion assembly]
GO:0097481 [neuronal postsynaptic density]
Show all
 5430 aa
620.4 kDa 		No 0
MACF1-003
ENSP00000362016
ENST00000372925
H0Y390 [Direct mapping]
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0007050 [cell cycle arrest]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016055 [Wnt signaling pathway]
GO:0016887 [ATPase activity]
Show all
 4434 aa
505.6 kDa 		No 0
MACF1-005
ENSP00000289893
ENST00000289893
Q9UPN3 [Direct mapping]
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0007050 [cell cycle arrest]
GO:0008152 [metabolic process]
GO:0010632 [regulation of epithelial cell migration]
GO:0016887 [ATPase activity]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0032587 [ruffle membrane]
GO:0032886 [regulation of microtubule-based process]
GO:0042060 [wound healing]
GO:0043001 [Golgi to plasma membrane protein transport]
GO:0044822 [poly(A) RNA binding]
GO:0045773 [positive regulation of axon extension]
GO:0051015 [actin filament binding]
GO:0051893 [regulation of focal adhesion assembly]
Show all
 5938 aa
670.1 kDa 		No 0
MACF1-007
ENSP00000407776
ENST00000442046
H0Y6T5 [Direct mapping]
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005509 [calcium ion binding]
GO:0007050 [cell cycle arrest]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016055 [Wnt signaling pathway]
GO:0016887 [ATPase activity]
Show all
 368 aa
39.7 kDa 		No 0
MACF1-010
ENSP00000353231
ENST00000360115
H0Y314 [Direct mapping]
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0007050 [cell cycle arrest]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016055 [Wnt signaling pathway]
GO:0016887 [ATPase activity]
Show all
 543 aa
60.9 kDa 		No 0
MACF1-011
ENSP00000391512
ENST00000446276
H0Y4F5 [Direct mapping]
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005509 [calcium ion binding]
GO:0007050 [cell cycle arrest]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016055 [Wnt signaling pathway]
GO:0016887 [ATPase activity]
Show all
 455 aa
50.5 kDa 		No 0
MACF1-012
ENSP00000434859
ENST00000484793
B4DQX9 [Direct mapping]
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5; cDNA FLJ59962, moderately similar to Microtubule-actin crosslinking factor 1(Actin cross-linking family 7)
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 121 aa
13.7 kDa 		No 0
MACF1-016
ENSP00000435892
ENST00000494012
E9PS75 [Direct mapping]
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   Phobius predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016021 [integral component of membrane]
GO:0016055 [Wnt signaling pathway]
GO:0016887 [ATPase activity]
Show all
 113 aa
13.4 kDa 		No 1
MACF1-024
ENSP00000412910
ENST00000422234
H0Y7I1 [Direct mapping]
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005856 [cytoskeleton]
GO:0007010 [cytoskeleton organization]
GO:0007050 [cell cycle arrest]
GO:0008092 [cytoskeletal protein binding]
Show all
 159 aa
17.6 kDa 		No 0
MACF1-025
ENSP00000433104
ENST00000482035
H0YD69 [Direct mapping]
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
Show all
 362 aa
39.3 kDa 		No 0
MACF1-028
ENSP00000362006
ENST00000372915
Q9UPN3 [Direct mapping]
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005856 [cytoskeleton]
GO:0005874 [microtubule]
GO:0005886 [plasma membrane]
GO:0007050 [cell cycle arrest]
GO:0008152 [metabolic process]
GO:0010632 [regulation of epithelial cell migration]
GO:0016887 [ATPase activity]
GO:0030177 [positive regulation of Wnt signaling pathway]
GO:0032587 [ruffle membrane]
GO:0032886 [regulation of microtubule-based process]
GO:0042060 [wound healing]
GO:0043001 [Golgi to plasma membrane protein transport]
GO:0044822 [poly(A) RNA binding]
GO:0045773 [positive regulation of axon extension]
GO:0051015 [actin filament binding]
GO:0051893 [regulation of focal adhesion assembly]
Show all
 7388 aa
838.3 kDa 		No 0
MACF1-029
ENSP00000437059
ENST00000530262
E9PNZ4 [Direct mapping]
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016055 [Wnt signaling pathway]
GO:0016887 [ATPase activity]
Show all
 2028 aa
231.1 kDa 		No 0
MACF1-030
ENSP00000435070
ENST00000524432
E9PLY5 [Direct mapping]
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5
Show all
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005515 [protein binding]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016055 [Wnt signaling pathway]
GO:0016887 [ATPase activity]
Show all
 1375 aa
159.9 kDa 		No 0
MACF1-031
ENSP00000455823
ENST00000567887
H3BQK9 [Direct mapping]
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5
Show all
   SCAMPI predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005856 [cytoskeleton]
GO:0007050 [cell cycle arrest]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016055 [Wnt signaling pathway]
GO:0016887 [ATPase activity]
Show all
 7592 aa
861.1 kDa 		No 0
MACF1-032
ENSP00000455274
ENST00000564288
H3BPE1 [Direct mapping]
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5
Show all
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005856 [cytoskeleton]
GO:0007050 [cell cycle arrest]
GO:0008017 [microtubule binding]
GO:0008152 [metabolic process]
GO:0016055 [Wnt signaling pathway]
GO:0016887 [ATPase activity]
Show all
 7555 aa
856.9 kDa 		No 0
MACF1-033
ENSP00000473615
ENST00000602421
B4DQX9 [Direct mapping]
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5; cDNA FLJ59962, moderately similar to Microtubule-actin crosslinking factor 1(Actin cross-linking family 7)
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 121 aa
13.7 kDa 		No 0
MACF1-034
ENSP00000431179
ENST00000530275
A0A0A6YYJ5 [Direct mapping]
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
 1427 aa
150.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.