Fields »
ABOUT
HELP
BLOG
GNGT1

GENERAL INFORMATION

Gene name

 GNGT1

Gene description

 Guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1

Protein class

 Predicted intracellular proteins
RAS pathway related proteins

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enriched (placenta)
GTEx:Not detected
FANTOM5:Tissue enriched (retina)

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression in rods.

DATA RELIABILITY

Data reliability
description

 External characterization data supports antibody staining but no internal RNA data available for correlation.

Reliability score

 Supported based on 1 antibody.
HPA042721
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Eye
N/A
Retina
N/A
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Retina

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (placenta)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Not detected
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (retina)

GENE INFORMATION

Gene name

 GNGT1 (HGNC Symbol)

Synonyms

 GNG1

Description

 Guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 (HGNC Symbol)

Entrez gene summary

 Heterotrimeric guanine nucleotide-binding proteins (G proteins) transduce extracellular signals received by transmembrane receptors to effector proteins. Transducin is a guanine nucleotide-binding protein found specifically in rod outer segments, where it mediates activation by rhodopsin of a cyclic GTP-specific (guanosine monophosphate) phosphodiesterase. Transducin is also referred to as GMPase. GNGT1 encodes the gamma subunit of transducin (Hurley et al., 1984 [PubMed 6438626]; Scherer et al., 1996 [PubMed 8661128]).[supplied by OMIM, Mar 2008]

Chromosome

 7

Cytoband

 q21.3

Chromosome location (bp)

 93591573 - 93911265

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000127928 (version 83.38)

Entrez gene

 2792

UniProt

 P63211 (UniProt - Evidence at protein level)

neXtProt

 NX_P63211

Antibodypedia

 GNGT1 antibodies

PROTEIN BROWSER
GNGT1-001
GNGT1-002
GNGT1-003
GNGT1-004
GNGT1-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GNGT1-001
ENSP00000248572
ENST00000248572
P63211 [Direct mapping]
Guanine nucleotide-binding protein G(T) subunit gamma-T1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Protein evidence (Kim et al 2014)
Show all
GO:0001750 [photoreceptor outer segment]
GO:0001917 [photoreceptor inner segment]
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007602 [phototransduction]
GO:0007603 [phototransduction, visible light]
GO:0008104 [protein localization]
GO:0010659 [cardiac muscle cell apoptotic process]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0042462 [eye photoreceptor cell development]
GO:0071456 [cellular response to hypoxia]
GO:0097381 [photoreceptor disc membrane]
Show all
 74 aa
8.5 kDa 		No 0
GNGT1-002
ENSP00000388777
ENST00000429473
P63211 [Direct mapping]
Guanine nucleotide-binding protein G(T) subunit gamma-T1
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007603 [phototransduction, visible light]
GO:0016056 [rhodopsin mediated signaling pathway]
GO:0022400 [regulation of rhodopsin mediated signaling pathway]
GO:0097381 [photoreceptor disc membrane]
Show all
 74 aa
8.5 kDa 		No 0
GNGT1-003
ENSP00000395756
ENST00000430875
C9JGI9 [Direct mapping]
Guanine nucleotide-binding protein subunit gamma
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0004871 [signal transducer activity]
GO:0005834 [heterotrimeric G-protein complex]
GO:0007186 [G-protein coupled receptor signaling pathway]
Show all
 46 aa
5.5 kDa 		No 0
GNGT1-004
ENSP00000401781
ENST00000428834
C9JGI9 [Direct mapping]
Guanine nucleotide-binding protein subunit gamma
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0004871 [signal transducer activity]
GO:0005834 [heterotrimeric G-protein complex]
GO:0007186 [G-protein coupled receptor signaling pathway]
Show all
 46 aa
5.5 kDa 		No 0
GNGT1-005
ENSP00000395857
ENST00000455502
C9JGI9 [Direct mapping]
Guanine nucleotide-binding protein subunit gamma
Show all
Predicted intracellular proteins
RAS pathway related proteins
Show all
GO:0004871 [signal transducer activity]
GO:0005834 [heterotrimeric G-protein complex]
GO:0007186 [G-protein coupled receptor signaling pathway]
Show all
 46 aa
5.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.