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HIP1

CANCER ATLAS

Gene description

 Huntingtin interacting protein 1

Protein class

 Cancer-related genes, Disease related genes, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Glioma

STAINING SUMMARY
HPA013606
HPA017964
CAB015334
CAB016402

GENE INFORMATION

Gene name

 HIP1 (HGNC Symbol)

Synonyms

 ILWEQ

Description

 Huntingtin interacting protein 1 (HGNC Symbol)

Entrez gene summary

 The product of this gene is a membrane-associated protein that functions in clathrin-mediated endocytosis and protein trafficking within the cell. The encoded protein binds to the huntingtin protein in the brain; this interaction is lost in Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Chromosome

 7

Cytoband

 q11.23

Chromosome location (bp)

 75533300 - 75738962

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000127946 (version 83.38)

Entrez gene

 3092

UniProt

 O00291 (UniProt - Evidence at protein level)

neXtProt

 NX_O00291

Antibodypedia

 HIP1 antibodies

PROTEIN BROWSER
HIP1-001
HIP1-002
HIP1-004
HIP1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
HIP1-001
ENSP00000336747
ENST00000336926
O00291 [Direct mapping]
Huntingtin-interacting protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005856 [cytoskeleton]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006897 [endocytosis]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0016020 [membrane]
GO:0030136 [clathrin-coated vesicle]
GO:0030154 [cell differentiation]
GO:0030276 [clathrin binding]
GO:0030665 [clathrin-coated vesicle membrane]
GO:0035091 [phosphatidylinositol binding]
GO:0042981 [regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048260 [positive regulation of receptor-mediated endocytosis]
GO:0048268 [clathrin coat assembly]
GO:0072583 [clathrin-mediated endocytosis]
GO:0097190 [apoptotic signaling pathway]
Show all
 1037 aa
116.2 kDa 		No 0
HIP1-002
ENSP00000410300
ENST00000434438
O00291 [Direct mapping]
Huntingtin-interacting protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005856 [cytoskeleton]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0016020 [membrane]
GO:0030136 [clathrin-coated vesicle]
GO:0030154 [cell differentiation]
GO:0030276 [clathrin binding]
GO:0030665 [clathrin-coated vesicle membrane]
GO:0035091 [phosphatidylinositol binding]
GO:0042981 [regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048260 [positive regulation of receptor-mediated endocytosis]
GO:0048268 [clathrin coat assembly]
GO:0072583 [clathrin-mediated endocytosis]
GO:0097190 [apoptotic signaling pathway]
Show all
 986 aa
110.7 kDa 		No 0
HIP1-004
ENSP00000414280
ENST00000420909
C9JMG5 [Direct mapping]
Huntingtin-interacting protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005543 [phospholipid binding]
GO:0006915 [apoptotic process]
GO:0030136 [clathrin-coated vesicle]
GO:0030276 [clathrin binding]
GO:0035091 [phosphatidylinositol binding]
GO:0048268 [clathrin coat assembly]
GO:0072583 [clathrin-mediated endocytosis]
Show all
 146 aa
16.9 kDa 		No 0
HIP1-201
ENSP00000484528
ENST00000616821
O00291 [Direct mapping]
Huntingtin-interacting protein 1
Show all
Predicted intracellular proteins
Cancer-related genes
   COSMIC somatic mutations in cancer genes
   COSMIC Somatic Mutations
   COSMIC Translocations
Disease related genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003779 [actin binding]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005543 [phospholipid binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0005856 [cytoskeleton]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006915 [apoptotic process]
GO:0006919 [activation of cysteine-type endopeptidase activity involved in apoptotic process]
GO:0016020 [membrane]
GO:0030136 [clathrin-coated vesicle]
GO:0030154 [cell differentiation]
GO:0030276 [clathrin binding]
GO:0030665 [clathrin-coated vesicle membrane]
GO:0035091 [phosphatidylinositol binding]
GO:0042981 [regulation of apoptotic process]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0048260 [positive regulation of receptor-mediated endocytosis]
GO:0048268 [clathrin coat assembly]
GO:0072583 [clathrin-mediated endocytosis]
GO:0097190 [apoptotic signaling pathway]
Show all
 1008 aa
113.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.