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GNAI1

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GENERAL INFORMATION

Gene name

 GNAI1

Gene description

 Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the centrosome. In addition localized to the nucleus & nucleoli. Caution: Based on antibodies targeting proteins from multiple genes.

RNA cell category

 Mixed

Protein evidence

 Evidence at protein level

Main location

 Localized to the Centrosome (supported)

Additional location

 In addition localized to the Nucleus (approved), Nucleoli (approved)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA042141
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Mixed
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the centrosome. In addition localized to the nucleus & nucleoli. Caution: Based on antibodies targeting proteins from multiple genes.

Main location

 Centrosome (supported)

Additional location

 Nucleus (approved), Nucleoli (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA042141 A-431 Centrosome
HPA042141 A549 Nucleus
Nucleoli
Centrosome
HPA042141 U-2 OS No staining    

GENE INFORMATION

Gene name

 GNAI1

Synonyms

Description

 Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 (HGNC Symbol)

Entrez gene summary

 Guanine nucleotide binding proteins are heterotrimeric signal-transducing molecules consisting of alpha, beta, and gamma subunits. The alpha subunit binds guanine nucleotide, can hydrolyze GTP, and can interact with other proteins. The protein encoded by this gene represents the alpha subunit of an inhibitory complex. The encoded protein is part of a complex that responds to beta-adrenergic signals by inhibiting adenylate cyclase. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]

Chromosome

 7

Cytoband

 q21.11

Chromosome location (bp)

 80133955 - 80219402

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000127955 (version 83.38)

Entrez gene

 2770

UniProt

 P63096 (UniProt - Evidence at protein level)

neXtProt

 NX_P63096

Antibodypedia

 GNAI1 antibodies

PROTEIN BROWSER
GNAI1-001
GNAI1-002
GNAI1-003
GNAI1-004
GNAI1-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
GNAI1-001
ENSP00000343027
ENST00000351004
P63096 [Direct mapping]
Guanine nucleotide-binding protein G(i) subunit alpha-1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005813 [centrosome]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007596 [blood coagulation]
GO:0008152 [metabolic process]
GO:0016020 [membrane]
GO:0019001 [guanyl nucleotide binding]
GO:0019003 [GDP binding]
GO:0030168 [platelet activation]
GO:0030496 [midbody]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031821 [G-protein coupled serotonin receptor binding]
GO:0032794 [GTPase activating protein binding]
GO:0043234 [protein complex]
GO:0043434 [response to peptide hormone]
GO:0045121 [membrane raft]
GO:0046872 [metal ion binding]
GO:0050805 [negative regulation of synaptic transmission]
GO:0051301 [cell division]
GO:0070062 [extracellular exosome]
Show all
 354 aa
40.4 kDa 		No 0
GNAI1-002
ENSP00000410572
ENST00000457358
P63096 [Direct mapping]
Guanine nucleotide-binding protein G(i) subunit alpha-1
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005515 [protein binding]
GO:0005525 [GTP binding]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0005765 [lysosomal membrane]
GO:0005813 [centrosome]
GO:0005834 [heterotrimeric G-protein complex]
GO:0005886 [plasma membrane]
GO:0007049 [cell cycle]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0007193 [adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway]
GO:0007268 [synaptic transmission]
GO:0007596 [blood coagulation]
GO:0008152 [metabolic process]
GO:0019001 [guanyl nucleotide binding]
GO:0030168 [platelet activation]
GO:0030496 [midbody]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031821 [G-protein coupled serotonin receptor binding]
GO:0043434 [response to peptide hormone]
GO:0046872 [metal ion binding]
GO:0051301 [cell division]
GO:0070062 [extracellular exosome]
Show all
 302 aa
34.8 kDa 		No 0
GNAI1-003
ENSP00000389435
ENST00000418742
C9JPP4 [Direct mapping]
Guanine nucleotide-binding protein G(i) subunit alpha-1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0005525 [GTP binding]
GO:0007165 [signal transduction]
GO:0007186 [G-protein coupled receptor signaling pathway]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0008152 [metabolic process]
GO:0019001 [guanyl nucleotide binding]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031821 [G-protein coupled serotonin receptor binding]
Show all
 144 aa
16.4 kDa 		No 0
GNAI1-004
ENSP00000391439
ENST00000442586
C9J2Z2 [Direct mapping]
Guanine nucleotide-binding protein G(i) subunit alpha-1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004871 [signal transducer activity]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031821 [G-protein coupled serotonin receptor binding]
Show all
 23 aa
2.5 kDa 		No 0
GNAI1-006
ENSP00000388347
ENST00000447650
C9JL77 [Direct mapping]
Guanine nucleotide-binding protein G(i) subunit alpha-1
Show all
Predicted intracellular proteins
Cancer-related genes
   Mutational cancer driver genes
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003924 [GTPase activity]
GO:0004871 [signal transducer activity]
GO:0007165 [signal transduction]
GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway]
GO:0008152 [metabolic process]
GO:0019001 [guanyl nucleotide binding]
GO:0031683 [G-protein beta/gamma-subunit complex binding]
GO:0031821 [G-protein coupled serotonin receptor binding]
Show all
 41 aa
4.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.