Expression of PEX1 in cancer - Summary - The Human Protein Atlas

CANCER ATLAS

Gene description

Peroxisomal biogenesis factor 1

Protein class

Disease related genes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Transporters

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA020235

GENE INFORMATION
Gene name	PEX1 (HGNC Symbol)
Synonyms	ZWS, ZWS1
Description	Peroxisomal biogenesis factor 1 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the AAA ATPase family, a large group of ATPases associated with diverse cellular activities. This protein is cytoplasmic but is often anchored to a peroxisomal membrane where it forms a heteromeric complex and plays a role in the import of proteins into peroxisomes and peroxisome biogenesis. Mutations in this gene have been associated with complementation group 1 peroxisomal disorders such as neonatal adrenoleukodystrophy, infantile Refsum disease, and Zellweger syndrome. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2013]
Chromosome	7
Cytoband	q21.2
Chromosome location (bp)	92487020 - 92528531
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000127980 (version 83.38)
Entrez gene	5189
UniProt	O43933 (UniProt - Evidence at protein level)
neXtProt	NX_O43933
Antibodypedia	PEX1 antibodies

PROTEIN BROWSER

PEX1-001	PEX1-002	PEX1-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PEX1-001 ENSP00000248633 ENST00000248633	O43933 [Direct mapping] Peroxisome biogenesis factor 1 Show all	Transporters Primary Active Transporters Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005777 [peroxisome] GO:0005778 [peroxisomal membrane] GO:0005829 [cytosol] GO:0006625 [protein targeting to peroxisome] GO:0007031 [peroxisome organization] GO:0008022 [protein C-terminus binding] GO:0008152 [metabolic process] GO:0016558 [protein import into peroxisome matrix] GO:0032403 [protein complex binding] GO:0042623 [ATPase activity, coupled] GO:0043231 [intracellular membrane-bounded organelle] GO:0060152 [microtubule-based peroxisome localization] GO:0070062 [extracellular exosome] Show all	1283 aa 142.9 kDa	No	0
PEX1-002 ENSP00000410438 ENST00000438045	O43933 [Direct mapping] Peroxisome biogenesis factor 1 Show all	Transporters Primary Active Transporters Predicted intracellular proteins Plasma proteins Disease related genes Potential drug targets Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0005777 [peroxisome] GO:0005778 [peroxisomal membrane] GO:0005829 [cytosol] GO:0006625 [protein targeting to peroxisome] GO:0007031 [peroxisome organization] GO:0008022 [protein C-terminus binding] GO:0008152 [metabolic process] GO:0016558 [protein import into peroxisome matrix] GO:0032403 [protein complex binding] GO:0042623 [ATPase activity, coupled] GO:0043231 [intracellular membrane-bounded organelle] GO:0060152 [microtubule-based peroxisome localization] GO:0070062 [extracellular exosome] Show all	961 aa 106 kDa	No	0
PEX1-004 ENSP00000394413 ENST00000428214	A0A0C4DG33 [Direct mapping] Peroxisome biogenesis factor 1; Peroxisome biogenesis factor 1, isoform CRA_c Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005524 [ATP binding] GO:0005777 [peroxisome] GO:0005778 [peroxisomal membrane] GO:0006625 [protein targeting to peroxisome] GO:0007031 [peroxisome organization] GO:0008152 [metabolic process] GO:0042623 [ATPase activity, coupled] Show all	1226 aa 136.6 kDa	No	0