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PAICS

CANCER ATLAS

Gene description

 Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase

Protein class

 Enzymes, Plasma proteins, Predicted intracellular proteins

Protein evidence

 Evidence at protein level
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA035895

GENE INFORMATION

Gene name

 PAICS (HGNC Symbol)

Synonyms

 ADE2H1, AIRC, PAIS

Description

 Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (HGNC Symbol)

Entrez gene summary

 This gene encodes a bifunctional enzyme containing phosphoribosylaminoimidazole carboxylase activity in its N-terminal region and phosphoribosylaminoimidazole succinocarboxamide synthetase in its C-terminal region. It catalyzes steps 6 and 7 of purine biosynthesis. The gene is closely linked and divergently transcribed with a locus that encodes an enzyme in the same pathway, and transcription of the two genes is coordinately regulated. The human genome contains several pseudogenes of this gene. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 4

Cytoband

 q12

Chromosome location (bp)

 56435741 - 56464579

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000128050 (version 83.38)

Entrez gene

 10606

UniProt

 P22234 (UniProt - Evidence at protein level)

neXtProt

 NX_P22234

Antibodypedia

 PAICS antibodies

PROTEIN BROWSER
PAICS-001
PAICS-002
PAICS-003
PAICS-006
PAICS-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PAICS-001
ENSP00000424053
ENST00000505164
E9PBS1 [Direct mapping]
Multifunctional protein ADE2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004639 [phosphoribosylaminoimidazolesuccinocarboxamide synthase activity]
GO:0005524 [ATP binding]
GO:0006164 [purine nucleotide biosynthetic process]
GO:0006189 ['de novo' IMP biosynthetic process]
Show all
 413 aa
45.7 kDa 		No 0
PAICS-002
ENSP00000424907
ENST00000514888
D6RF62 [Direct mapping]
Multifunctional protein ADE2; Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase, isoform CRA_b
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004639 [phosphoribosylaminoimidazolesuccinocarboxamide synthase activity]
GO:0005524 [ATP binding]
GO:0006164 [purine nucleotide biosynthetic process]
GO:0006189 ['de novo' IMP biosynthetic process]
Show all
 333 aa
37.1 kDa 		No 0
PAICS-003
ENSP00000382595
ENST00000399688
P22234 [Direct mapping]
Multifunctional protein ADE2 Phosphoribosylaminoimidazole-succinocarboxamide synthase Phosphoribosylaminoimidazole carboxylase
Show all
Enzymes
   ENZYME proteins
   Lyases
   Ligase
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004638 [phosphoribosylaminoimidazole carboxylase activity]
GO:0004639 [phosphoribosylaminoimidazolesuccinocarboxamide synthase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006144 [purine nucleobase metabolic process]
GO:0006164 [purine nucleotide biosynthetic process]
GO:0006189 ['de novo' IMP biosynthetic process]
GO:0009113 [purine nucleobase biosynthetic process]
GO:0009168 [purine ribonucleoside monophosphate biosynthetic process]
GO:0016020 [membrane]
GO:0042802 [identical protein binding]
GO:0044281 [small molecule metabolic process]
GO:0046084 [adenine biosynthetic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0070062 [extracellular exosome]
Show all
 432 aa
48 kDa 		No 0
PAICS-006
ENSP00000421096
ENST00000512576
P22234 [Direct mapping]
Multifunctional protein ADE2 Phosphoribosylaminoimidazole-succinocarboxamide synthase Phosphoribosylaminoimidazole carboxylase
A0A024RD93 [Target identity:100%; Query identity:100%]
Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase, isoform CRA_c
Show all
Enzymes
   ENZYME proteins
   Lyases
   Ligase
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004638 [phosphoribosylaminoimidazole carboxylase activity]
GO:0004639 [phosphoribosylaminoimidazolesuccinocarboxamide synthase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006144 [purine nucleobase metabolic process]
GO:0006164 [purine nucleotide biosynthetic process]
GO:0006189 ['de novo' IMP biosynthetic process]
GO:0009113 [purine nucleobase biosynthetic process]
GO:0009168 [purine ribonucleoside monophosphate biosynthetic process]
GO:0016020 [membrane]
GO:0042802 [identical protein binding]
GO:0044281 [small molecule metabolic process]
GO:0046084 [adenine biosynthetic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0070062 [extracellular exosome]
Show all
 425 aa
47.1 kDa 		No 0
PAICS-201
ENSP00000264221
ENST00000264221
P22234 [Direct mapping]
Multifunctional protein ADE2 Phosphoribosylaminoimidazole-succinocarboxamide synthase Phosphoribosylaminoimidazole carboxylase
A0A024RD93 [Target identity:100%; Query identity:100%]
Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase, isoform CRA_c
Show all
Enzymes
   ENZYME proteins
   Lyases
   Ligase
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004638 [phosphoribosylaminoimidazole carboxylase activity]
GO:0004639 [phosphoribosylaminoimidazolesuccinocarboxamide synthase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005829 [cytosol]
GO:0006144 [purine nucleobase metabolic process]
GO:0006164 [purine nucleotide biosynthetic process]
GO:0006189 ['de novo' IMP biosynthetic process]
GO:0009113 [purine nucleobase biosynthetic process]
GO:0009168 [purine ribonucleoside monophosphate biosynthetic process]
GO:0016020 [membrane]
GO:0042802 [identical protein binding]
GO:0044281 [small molecule metabolic process]
GO:0046084 [adenine biosynthetic process]
GO:0055086 [nucleobase-containing small molecule metabolic process]
GO:0070062 [extracellular exosome]
Show all
 425 aa
47.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.