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DGCR8

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GENERAL INFORMATION

Gene name

 DGCR8

Gene description

 DGCR8 microprocessor complex subunit

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 DGCR8 (HGNC Symbol)

Synonyms

 C22orf12, DGCRK6, Gy1, pasha

Description

 DGCR8 microprocessor complex subunit (HGNC Symbol)

Entrez gene summary

 This gene encodes a subunit of the microprocessor complex which mediates the biogenesis of microRNAs from the primary microRNA transcript. The encoded protein is a double-stranded RNA binding protein that functions as the non-catalytic subunit of the microprocessor complex. This protein is required for binding the double-stranded RNA substrate and facilitates cleavage of the RNA by the ribonuclease III protein, Drosha. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

Chromosome

 22

Cytoband

 q11.21

Chromosome location (bp)

 20080232 - 20111877

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000128191 (version 83.38)

Entrez gene

 54487

UniProt

 Q8WYQ5 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WYQ5

Antibodypedia

 DGCR8 antibodies

PROTEIN BROWSER
DGCR8-001
DGCR8-003
DGCR8-009
DGCR8-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
DGCR8-001
ENSP00000263209
ENST00000351989
Q8WYQ5 [Direct mapping]
Microprocessor complex subunit DGCR8
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003725 [double-stranded RNA binding]
GO:0004525 [ribonuclease III activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0010467 [gene expression]
GO:0015630 [microtubule cytoskeleton]
GO:0020037 [heme binding]
GO:0031047 [gene silencing by RNA]
GO:0031053 [primary miRNA processing]
GO:0042803 [protein homodimerization activity]
GO:0046872 [metal ion binding]
GO:0070877 [microprocessor complex]
GO:0070878 [primary miRNA binding]
GO:0072091 [regulation of stem cell proliferation]
GO:0090501 [RNA phosphodiester bond hydrolysis]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
Show all
 773 aa
86 kDa 		No 0
DGCR8-003
ENSP00000384726
ENST00000407755
Q8WYQ5 [Direct mapping]
Microprocessor complex subunit DGCR8
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003725 [double-stranded RNA binding]
GO:0004525 [ribonuclease III activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0010467 [gene expression]
GO:0015630 [microtubule cytoskeleton]
GO:0020037 [heme binding]
GO:0031047 [gene silencing by RNA]
GO:0031053 [primary miRNA processing]
GO:0042803 [protein homodimerization activity]
GO:0046872 [metal ion binding]
GO:0070877 [microprocessor complex]
GO:0070878 [primary miRNA binding]
GO:0090501 [RNA phosphodiester bond hydrolysis]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
Show all
 740 aa
82.7 kDa 		No 0
DGCR8-009
ENSP00000409625
ENST00000457069
C9JSD5 [Direct mapping]
Microprocessor complex subunit DGCR8
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 125 aa
13.2 kDa 		No 0
DGCR8-201
ENSP00000372488
ENST00000383024
Q8WYQ5 [Direct mapping]
Microprocessor complex subunit DGCR8
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003725 [double-stranded RNA binding]
GO:0004525 [ribonuclease III activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0010467 [gene expression]
GO:0015630 [microtubule cytoskeleton]
GO:0020037 [heme binding]
GO:0031047 [gene silencing by RNA]
GO:0031053 [primary miRNA processing]
GO:0042803 [protein homodimerization activity]
GO:0046872 [metal ion binding]
GO:0070877 [microprocessor complex]
GO:0070878 [primary miRNA binding]
GO:0090501 [RNA phosphodiester bond hydrolysis]
GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic]
Show all
 740 aa
82.7 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.