Expression of MGAT3 in cancer - Summary

CANCER ATLAS

Gene description

Mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase

Protein class

Enzymes, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA017598

GENE INFORMATION
Gene name	MGAT3 (HGNC Symbol)
Synonyms	GNT-III
Description	Mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase (HGNC Symbol)
Entrez gene summary	There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. The enzyme encoded by this gene transfers a GlcNAc residue to the beta-linked mannose of the trimannosyl core of N-linked oligosaccharides and produces a bisecting GlcNAc. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Chromosome	22
Cytoband	q13.1
Chromosome location (bp)	39457344 - 39492194
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000128268 (version 83.38)
Entrez gene	4248
UniProt	Q09327 (UniProt - Evidence at transcript level)
neXtProt	NX_Q09327
Antibodypedia	MGAT3 antibodies

PROTEIN BROWSER

MGAT3-001	MGAT3-002	MGAT3-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MGAT3-001 ENSP00000345270 ENST00000341184	Q09327 [Direct mapping] Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase Show all	Enzymes ENZYME proteins Transferases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000139 [Golgi membrane] GO:0003830 [beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity] GO:0006044 [N-acetylglucosamine metabolic process] GO:0006487 [protein N-linked glycosylation] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016757 [transferase activity, transferring glycosyl groups] GO:0018279 [protein N-linked glycosylation via asparagine] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0060070 [canonical Wnt signaling pathway] Show all	533 aa 61.3 kDa	Yes	0
MGAT3-002 ENSP00000416226 ENST00000429402	B0QY93 [Direct mapping] Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003830 [beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity] GO:0006487 [protein N-linked glycosylation] GO:0016020 [membrane] Show all	161 aa 18 kDa	Yes	0
MGAT3-003 ENSP00000408075 ENST00000418314	B0QY92 [Direct mapping] Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003830 [beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity] GO:0006487 [protein N-linked glycosylation] GO:0016021 [integral component of membrane] Show all	108 aa 12.1 kDa	No	0