Tissue expression of ADORA2A - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	ADORA2A
Gene description	Adenosine A2a receptor
Protein class	Cancer-related genes FDA approved drug targets G-protein coupled receptors Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (bone marrow)
GTEx:	Tissue enhanced (liver)
FANTOM5:	Tissue enhanced (caudate)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (bone marrow)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (liver)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (caudate)

GENE INFORMATION
Gene name	ADORA2A (HGNC Symbol)
Synonyms	ADORA2, RDC8
Description	Adenosine A2a receptor (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily, which is subdivided into classes and subtypes. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein, an adenosine receptor of A2A subtype, uses adenosine as the preferred endogenous agonist and preferentially interacts with the G(s) and G(olf) family of G proteins to increase intracellular cAMP levels. It plays an important role in many biological functions, such as cardiac rhythm and circulation, cerebral and renal blood flow, immune function, pain regulation, and sleep. It has been implicated in pathophysiological conditions such as inflammatory diseases and neurodegenerative disorders. Alternative splicing results in multiple transcript variants. A read-through transcript composed of the upstream SPECC1L (sperm antigen with calponin homology and coiled-coil domains 1-like) and ADORA2A (adenosine A2a receptor) gene sequence has been identified, but it is thought to be non-coding. [provided by RefSeq, Jun 2013]
Chromosome	22
Cytoband	q11.23
Chromosome location (bp)	24417879 - 24442360
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000128271 (version 83.38)
Entrez gene	135
UniProt	P29274 (UniProt - Evidence at protein level)
neXtProt	NX_P29274
Antibodypedia	ADORA2A antibodies

PROTEIN BROWSER

ADORA2A-001	ADORA2A-002	ADORA2A-003	ADORA2A-005	ADORA2A-008	ADORA2A-009	ADORA2A-011	ADORA2A-012	ADORA2A-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ADORA2A-001 ENSP00000336630 ENST00000337539	P29274 [Direct mapping] Adenosine receptor A2a X5DNB4 [Target identity:100%; Query identity:100%] Adenosine receptor A2 Show all	Transporters G-protein coupled receptors GPCRs excl olfactory receptors Adenosine and adenine nucleotide receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Cancer-related genes Mutational cancer driver genes FDA approved drug targets Small molecule drugs Show all	GO:0001609 [G-protein coupled adenosine receptor activity] GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006171 [cAMP biosynthetic process] GO:0006909 [phagocytosis] GO:0006915 [apoptotic process] GO:0006954 [inflammatory response] GO:0006968 [cellular defense response] GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0007188 [adenylate cyclase-modulating G-protein coupled receptor signaling pathway] GO:0007190 [activation of adenylate cyclase activity] GO:0007267 [cell-cell signaling] GO:0007417 [central nervous system development] GO:0007596 [blood coagulation] GO:0007600 [sensory perception] GO:0008015 [blood circulation] GO:0010579 [positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0019899 [enzyme binding] GO:0042802 [identical protein binding] GO:0044267 [cellular protein metabolic process] GO:0048011 [neurotrophin TRK receptor signaling pathway] Show all	412 aa 44.7 kDa	No	7
ADORA2A-002 ENSP00000474097 ENST00000496258	S4R3A7 [Direct mapping] Adenosine receptor A2a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Cancer-related genes Mutational cancer driver genes Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	83 aa 8.7 kDa	No	2
ADORA2A-003 ENSP00000404497 ENST00000424232	C9JFS2 [Direct mapping] Adenosine receptor A2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Cancer-related genes Mutational cancer driver genes Show all	GO:0001609 [G-protein coupled adenosine receptor activity] GO:0001973 [adenosine receptor signaling pathway] GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	88 aa 9.2 kDa	No	2
ADORA2A-005 ENSP00000414802 ENST00000444262	C9JQD8 [Direct mapping] Adenosine receptor A2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Cancer-related genes Mutational cancer driver genes Show all	GO:0001609 [G-protein coupled adenosine receptor activity] GO:0001973 [adenosine receptor signaling pathway] GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	365 aa 40.1 kDa	No	7
ADORA2A-008 ENSP00000474895 ENST00000464977		Predicted intracellular proteins Cancer-related genes Mutational cancer driver genes Show all		6 aa 0.6 kDa	No	0
ADORA2A-009 ENSP00000473799 ENST00000486108	S4R2Z8 [Direct mapping] Adenosine receptor A2 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Cancer-related genes Mutational cancer driver genes Show all	GO:0001609 [G-protein coupled adenosine receptor activity] GO:0001973 [adenosine receptor signaling pathway] GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	108 aa 11.5 kDa	No	3
ADORA2A-011 ENSP00000475000 ENST00000472248	S4R429 [Direct mapping] Adenosine receptor A2a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Mutational cancer driver genes Show all	GO:0016021 [integral component of membrane] Show all	29 aa 3.1 kDa	No	1
ADORA2A-012 ENSP00000400190 ENST00000439591	C9J0Z4 [Direct mapping] Adenosine receptor A2a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Cancer-related genes Mutational cancer driver genes Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	76 aa 7.9 kDa	No	2
ADORA2A-015 ENSP00000397071 ENST00000436735	C9J3T2 [Direct mapping] Adenosine receptor A2a Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Cancer-related genes Mutational cancer driver genes Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	64 aa 6.7 kDa	No	2