Tissue expression of APOL3 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	APOL3
Gene description	Apolipoprotein L, 3
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Mixed
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Mixed
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	APOL3 (HGNC Symbol)
Synonyms	APOLIII, CG12-1
Description	Apolipoprotein L, 3 (HGNC Symbol)
Entrez gene summary	This gene is a member of the apolipoprotein L gene family, and it is present in a cluster with other family members on chromosome 22. The encoded protein is found in the cytoplasm, where it may affect the movement of lipids, including cholesterol, and/or allow the binding of lipids to organelles. In addition, expression of this gene is up-regulated by tumor necrosis factor-alpha in endothelial cells lining the normal and atherosclerotic iliac artery and aorta. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2015]
Chromosome	22
Cytoband	q12.3
Chromosome location (bp)	36140330 - 36166177
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000128284 (version 83.38)
Entrez gene	80833
UniProt	O95236 (UniProt - Evidence at protein level)
neXtProt	NX_O95236
Antibodypedia	APOL3 antibodies

PROTEIN BROWSER

APOL3-001	APOL3-002	APOL3-003	APOL3-007	APOL3-201	APOL3-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
APOL3-001 ENSP00000355164 ENST00000361710	O95236 [Direct mapping] Apolipoprotein L3 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004871 [signal transducer activity] GO:0005319 [lipid transporter activity] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0006869 [lipid transport] GO:0006954 [inflammatory response] GO:0007165 [signal transduction] GO:0008289 [lipid binding] GO:0016020 [membrane] GO:0042157 [lipoprotein metabolic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] Show all	202 aa 21.6 kDa	Yes	0
APOL3-002 ENSP00000380456 ENST00000397287	O95236 [Direct mapping] Apolipoprotein L3 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004871 [signal transducer activity] GO:0005319 [lipid transporter activity] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0006869 [lipid transport] GO:0006954 [inflammatory response] GO:0007165 [signal transduction] GO:0008289 [lipid binding] GO:0016020 [membrane] GO:0042157 [lipoprotein metabolic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] Show all	202 aa 21.6 kDa	Yes	0
APOL3-003 ENSP00000344577 ENST00000349314	O95236 [Direct mapping] Apolipoprotein L3 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins SignalP predicted secreted proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004871 [signal transducer activity] GO:0005319 [lipid transporter activity] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0006869 [lipid transport] GO:0006954 [inflammatory response] GO:0007165 [signal transduction] GO:0008289 [lipid binding] GO:0016020 [membrane] GO:0042157 [lipoprotein metabolic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] Show all	402 aa 44.3 kDa	No	0
APOL3-007 ENSP00000432271 ENST00000531095	H0YCT0 [Direct mapping] Apolipoprotein L3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		40 aa 4.3 kDa	No	0
APOL3-201 ENSP00000380461 ENST00000397293	O95236 [Direct mapping] Apolipoprotein L3 Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004871 [signal transducer activity] GO:0005319 [lipid transporter activity] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0006869 [lipid transport] GO:0006954 [inflammatory response] GO:0007165 [signal transduction] GO:0008289 [lipid binding] GO:0016020 [membrane] GO:0042157 [lipoprotein metabolic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] Show all	202 aa 21.6 kDa	Yes	0
APOL3-202 ENSP00000415779 ENST00000424878	O95236 [Direct mapping] Apolipoprotein L3 A0A024R1G6 [Target identity:100%; Query identity:100%] Apolipoprotein L, 3, isoform CRA_a Show all	MEMSAT3 predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004871 [signal transducer activity] GO:0005319 [lipid transporter activity] GO:0005576 [extracellular region] GO:0005737 [cytoplasm] GO:0006869 [lipid transport] GO:0006954 [inflammatory response] GO:0007165 [signal transduction] GO:0008289 [lipid binding] GO:0016020 [membrane] GO:0042157 [lipoprotein metabolic process] GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling] Show all	331 aa 36.5 kDa	No	0