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KRT17

GENERAL INFORMATION

Gene name

 KRT17

Gene description

 Keratin 17, type I

Protein class

 Cancer-related genes
Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Tissue enhanced (urinary bladder, seminal vesicle, breast)
GTEx:Tissue enhanced (skin, breast)
FANTOM5:Tissue enhanced (breast, tonsil)

Protein evidence

 Evidence at protein level

Protein expression

 Selective cytoplasmic and membranous expression mainly in squamous epithelia, urinary bladder, salivary gland, breast, prostate and respiratory tract.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.

Reliability score

 Supported based on 4 antibodies.
HPA000452 , HPA000453 , HPA045062 , CAB000029
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

Skin

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (urinary bladder, seminal vesicle, breast)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (skin, breast)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (breast, tonsil)

GENE INFORMATION

Gene name

 KRT17 (HGNC Symbol)

Synonyms

 PCHC1

Description

 Keratin 17, type I (HGNC Symbol)

Entrez gene summary

 This gene encodes the type I intermediate filament chain keratin 17, expressed in nail bed, hair follicle, sebaceous glands, and other epidermal appendages. Mutations in this gene lead to Jackson-Lawler type pachyonychia congenita and steatocystoma multiplex. [provided by RefSeq, Aug 2008]

Chromosome

 17

Cytoband

 q21.2

Chromosome location (bp)

 41619437 - 41624842

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000128422 (version 83.38)

Entrez gene

 3872

UniProt

 Q04695 (UniProt - Evidence at protein level)

neXtProt

 NX_Q04695

Antibodypedia

 KRT17 antibodies

PROTEIN BROWSER
KRT17-001
KRT17-002
KRT17-005
KRT17-006
KRT17-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KRT17-001
ENSP00000308452
ENST00000311208
Q04695 [Direct mapping]
Keratin, type I cytoskeletal 17
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0002009 [morphogenesis of an epithelium]
GO:0005198 [structural molecule activity]
GO:0005200 [structural constituent of cytoskeleton]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005882 [intermediate filament]
GO:0007165 [signal transduction]
GO:0008544 [epidermis development]
GO:0030307 [positive regulation of cell growth]
GO:0031069 [hair follicle morphogenesis]
GO:0031424 [keratinization]
GO:0032395 [MHC class II receptor activity]
GO:0042289 [MHC class II protein binding]
GO:0045109 [intermediate filament organization]
GO:0045727 [positive regulation of translation]
GO:0051798 [positive regulation of hair follicle development]
GO:0070062 [extracellular exosome]
GO:0071944 [cell periphery]
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 432 aa
48.1 kDa 		No 0
KRT17-002
ENSP00000468672
ENST00000463128
K7ESE1 [Direct mapping]
Keratin, type I cytoskeletal 17
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005198 [structural molecule activity]
GO:0005882 [intermediate filament]
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 95 aa
11 kDa 		No 0
KRT17-005
ENSP00000467418
ENST00000577817
K7EPJ9 [Direct mapping]
Keratin, type I cytoskeletal 17
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005198 [structural molecule activity]
GO:0005882 [intermediate filament]
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 231 aa
24.9 kDa 		No 0
KRT17-006
ENSP00000466166
ENST00000590038
K7ELP7 [Direct mapping]
Keratin, type I cytoskeletal 17
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005198 [structural molecule activity]
GO:0005882 [intermediate filament]
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 49 aa
5.5 kDa 		No 0
KRT17-201
ENSP00000441751
ENST00000540235
F5GWP8 [Direct mapping]
Keratin, type I cytoskeletal 17
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   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005198 [structural molecule activity]
GO:0005515 [protein binding]
GO:0005882 [intermediate filament]
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 349 aa
40.3 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.