Tissue expression of EMC4 - Summary - The Human Protein Atlas

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EMC4

TISSUE

CELL

CANCER

TISSUE ATLAS PRIMARY DATA

GENE/PROTEIN

Antibody validation

Dictionary


Tissue proteome

GENERAL INFORMATION
Gene name	EMC4
Gene description	ER membrane protein complex subunit 4
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	7
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Expressed in all
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

Protein expression

Cytoplasmic expression in a few tissues.

DATA RELIABILITY
Data reliability description	External characterization data supports antibody staining. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA053440
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RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

Cerebral cortex

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

Thyroid gland

Parathyroid gland

Adrenal gland

Bone marrow & immune system

Appendix

Bone marrow

Lymph node

Tonsil

Spleen

Muscle tissues

Heart muscle

Skeletal muscle

Smooth muscle

Lung

Nasopharynx

N/A

Bronchus

N/A

Lung

Liver & gallbladder

Liver

Gallbladder

Pancreas

Pancreas

Gastrointestinal tract

Oral mucosa

N/A

Salivary gland

Esophagus

Stomach

Duodenum

Small intestine

Colon

Rectum

Kidney & urinary bladder

Kidney

Urinary bladder

Male tissues

Testis

Epididymis

Prostate

Seminal vesicle

Female tissues

Breast

Vagina

N/A

Cervix, uterine

Endometrium

Fallopian tube

Ovary

Placenta

Adipose & soft tissue

Adipose tissue

Soft tissue

N/A

Skin

Skin

Cerebral cortex

PROTEIN EXPRESSION OVERVIEW
Organ Expression Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	EMC4 (HGNC Symbol)
Synonyms	FLJ90746, MGC24415, PIG17, TMEM85
Description	ER membrane protein complex subunit 4 (HGNC Symbol)
Entrez gene summary
Chromosome	15
Cytoband	q14
Chromosome location (bp)	34224999 - 34230156
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000128463 (version 83.38)
Entrez gene	51234
UniProt	Q5J8M3 (UniProt - Evidence at protein level)
neXtProt	NX_Q5J8M3
Antibodypedia	EMC4 antibodies

PROTEIN BROWSER

EMC4-001	EMC4-003	EMC4-008	EMC4-011	EMC4-012	EMC4-013	EMC4-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
EMC4-001 ENSP00000267750 ENST00000267750	Q5J8M3 [Direct mapping] ER membrane protein complex subunit 4 A0A024R9N3 [Target identity:100%; Query identity:100%] Transmembrane protein 85, isoform CRA_b Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0006915 [apoptotic process] GO:0016021 [integral component of membrane] GO:0072546 [ER membrane protein complex] Show all	183 aa 20.1 kDa	No	2
EMC4-003 ENSP00000249209 ENST00000249209	Q5J8M3 [Direct mapping] ER membrane protein complex subunit 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006915 [apoptotic process] GO:0016021 [integral component of membrane] GO:0072546 [ER membrane protein complex] Show all	149 aa 16.7 kDa	No	1
EMC4-008 ENSP00000453287 ENST00000561372	H0YLP8 [Direct mapping] ER membrane protein complex subunit 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	125 aa 13.9 kDa	No	1
EMC4-011 ENSP00000473881 ENST00000557879	S4R329 [Direct mapping] ER membrane protein complex subunit 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		72 aa 7.8 kDa	No	0
EMC4-012 ENSP00000452672 ENST00000559421	H0YK61 [Direct mapping] ER membrane protein complex subunit 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		78 aa 8.3 kDa	No	0
EMC4-013 ENSP00000454052 ENST00000559078	H0YNK8 [Direct mapping] ER membrane protein complex subunit 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		102 aa 11.2 kDa	No	0
EMC4-014 ENSP00000452849 ENST00000560947	H0YKL2 [Direct mapping] ER membrane protein complex subunit 4 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	98 aa 10.7 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.