Tissue expression of DOCK4 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	DOCK4
Gene description	Dedicator of cytokinesis 4
Protein class	Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (cerebral cortex)
GTEx:	Expressed in all
FANTOM5:	Expressed in all

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Expressed in all
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Expressed in all

GENE INFORMATION
Gene name	DOCK4 (HGNC Symbol)
Synonyms	FLJ34238, KIAA0716
Description	Dedicator of cytokinesis 4 (HGNC Symbol)
Entrez gene summary	This gene is a member of the dedicator of cytokinesis (DOCK) family and encodes a protein with a DHR-1 (CZH-1) domain, a DHR-2 (CZH-2) domain and an SH3 domain. This membrane-associated, cytoplasmic protein functions as a guanine nucleotide exchange factor and is involved in regulation of adherens junctions between cells. Mutations in this gene have been associated with ovarian, prostate, glioma, and colorectal cancers. Alternatively spliced variants which encode different protein isoforms have been described, but only one has been fully characterized. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q31.1
Chromosome location (bp)	111726110 - 112206411
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000128512 (version 83.38)
Entrez gene	9732
UniProt	Q8N1I0 (UniProt - Evidence at protein level)
neXtProt	NX_Q8N1I0
Antibodypedia	DOCK4 antibodies

PROTEIN BROWSER

DOCK4-001	DOCK4-004	DOCK4-005	DOCK4-007	DOCK4-010	DOCK4-012	DOCK4-013	DOCK4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DOCK4-001 ENSP00000404179 ENST00000437633	Q8N1I0 [Direct mapping] Dedicator of cytokinesis protein 4 Show all	Phobius predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0007264 [small GTPase mediated signal transduction] GO:0012505 [endomembrane system] GO:0014911 [positive regulation of smooth muscle cell migration] GO:0016020 [membrane] GO:0017124 [SH3 domain binding] GO:0030165 [PDZ domain binding] GO:0030971 [receptor tyrosine kinase binding] GO:0032420 [stereocilium] GO:0032421 [stereocilium bundle] GO:0043547 [positive regulation of GTPase activity] GO:0048365 [Rac GTPase binding] GO:0060326 [cell chemotaxis] GO:1904694 [negative regulation of vascular smooth muscle contraction] Show all	1966 aa 225.2 kDa	No	0
DOCK4-004 ENSP00000397412 ENST00000445943	H0Y599 [Direct mapping] Dedicator of cytokinesis protein 4 Show all	Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	1999 aa 228.5 kDa	No	0
DOCK4-005 ENSP00000410746 ENST00000428084	Q8N1I0 [Direct mapping] Dedicator of cytokinesis protein 4 Show all	Phobius predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0007264 [small GTPase mediated signal transduction] GO:0012505 [endomembrane system] GO:0014911 [positive regulation of smooth muscle cell migration] GO:0016020 [membrane] GO:0017124 [SH3 domain binding] GO:0030165 [PDZ domain binding] GO:0030971 [receptor tyrosine kinase binding] GO:0032420 [stereocilium] GO:0032421 [stereocilium bundle] GO:0043547 [positive regulation of GTPase activity] GO:0048365 [Rac GTPase binding] GO:0060326 [cell chemotaxis] GO:1904694 [negative regulation of vascular smooth muscle contraction] Show all	1975 aa 226.2 kDa	No	0
DOCK4-007 ENSP00000412834 ENST00000423057	H0Y7H7 [Direct mapping] Dedicator of cytokinesis protein 4 Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005622 [intracellular] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	1389 aa 158.9 kDa	No	0
DOCK4-010 ENSP00000403504 ENST00000417165	C9JDB3 [Direct mapping] Dedicator of cytokinesis protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005622 [intracellular] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	131 aa 15.4 kDa	No	0
DOCK4-012 ENSP00000406468 ENST00000450156	C9J637 [Direct mapping] Dedicator of cytokinesis protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005622 [intracellular] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	188 aa 22.8 kDa	No	0
DOCK4-013 ENSP00000406298 ENST00000437129	C9J7D9 [Direct mapping] Dedicator of cytokinesis protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005622 [intracellular] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	193 aa 23.5 kDa	No	0
DOCK4-201 ENSP00000440944 ENST00000494651	F5GXW1 [Direct mapping] Dedicator of cytokinesis protein 4 Show all	Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005085 [guanyl-nucleotide exchange factor activity] GO:0005515 [protein binding] GO:0005622 [intracellular] GO:0007264 [small GTPase mediated signal transduction] GO:0043547 [positive regulation of GTPase activity] Show all	1094 aa 126.1 kDa	No	0