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Several cases of liver, urothelial, skin, cervical, ovarian cancers and melanomas exhibited moderate to strong cytoplasmic/ nucleolar and occasional membranous positivity. Few breast, renal along with rare colorectal, testis, pancreatic, head and neck cancers showed moderate positivity. Remaining tissues were weakly stained or negative.
Cancer tissues showed weak to moderate cytoplasmic staining with additional membranous immunoreactivity in colorectal and prostate cancers. Few cases of carcinoids and testicular cancers were strongly positive. Several cases of gliomas, lymphomas, skin, liver and pancreatic cancers were negative.
Cancer cells showed weak to moderate cytoplasmic positivity. In some adenocarcinomas the staining was accentuated to the luminal membrane.
GENE INFORMATION
Gene name
ATP6V1F (HGNC Symbol)
Synonyms
ATP6S14, VATF, Vma7
Description
ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F (HGNC Symbol)
Entrez gene summary
This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c"", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is the V1 domain F subunit protein. [provided by RefSeq, Jul 2008]
Q16864 [Direct mapping] V-type proton ATPase subunit F
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Transporters Primary Active Transporters SCAMPI predicted membrane proteins Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014)
