Tissue expression of LRRC4 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	LRRC4
Gene description	Leucine rich repeat containing 4
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enhanced (cerebral cortex)
GTEx:	Tissue enhanced (cerebral cortex, cerebellum)
FANTOM5:	Tissue enhanced (cerebellum, brain)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebral cortex, cerebellum)
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (cerebellum, brain)

GENE INFORMATION
Gene name	LRRC4 (HGNC Symbol)
Synonyms	NAG14
Description	Leucine rich repeat containing 4 (HGNC Symbol)
Entrez gene summary	This gene is significantly downregulated in primary brain tumors. The exact function of the protein encoded by this gene is unknown. [provided by RefSeq, Jul 2008]
Chromosome	7
Cytoband	q32.1
Chromosome location (bp)	128027071 - 128032107
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000128594 (version 83.38)
Entrez gene	64101
UniProt	Q9HBW1 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HBW1
Antibodypedia	LRRC4 antibodies

PROTEIN BROWSER

LRRC4-001	LRRC4-002	LRRC4-003	LRRC4-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
LRRC4-001 ENSP00000249363 ENST00000249363	Q9HBW1 [Direct mapping] Leucine-rich repeat-containing protein 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0016021 [integral component of membrane] GO:0030054 [cell junction] GO:0043197 [dendritic spine] GO:0044309 [neuron spine] GO:0045202 [synapse] GO:0045211 [postsynaptic membrane] GO:0050807 [regulation of synapse organization] GO:0050808 [synapse organization] GO:0060076 [excitatory synapse] GO:0097119 [postsynaptic density protein 95 clustering] Show all	653 aa 72.7 kDa	No	1
LRRC4-002 ENSP00000418093 ENST00000476782	C9JA92 [Direct mapping] Leucine-rich repeat-containing protein 4 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	94 aa 10.4 kDa	No	0
LRRC4-003 ENSP00000417795 ENST00000478726	C9J7K7 [Direct mapping] Leucine-rich repeat-containing protein 4 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	51 aa 5.5 kDa	No	0
LRRC4-004 ENSP00000418254 ENST00000494115	C9J7V8 [Direct mapping] Leucine-rich repeat-containing protein 4 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	78 aa 9.1 kDa	No	0