Tissue expression of HOXD3 - Summary - The Human Protein Atlas

GENERAL INFORMATION
Gene name	HOXD3
Gene description	Homeobox D3
Protein class	Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category

HPA:	Tissue enriched (epididymis)
GTEx:	Mixed
FANTOM5:	Tissue enhanced (endometrium, epididymis)

Protein evidence

Evidence at protein level

DATA RELIABILITY
Reliability score	Pending normal tissue annotation.

RNA AND PROTEIN EXPRESSION SUMMARY

RNA expression (TPM)

Protein expression (score)

Brain

N/A

Cerebral cortex

N/A

Hippocampus

N/A

Caudate

N/A

Cerebellum

N/A

Endocrine tissues

N/A

Thyroid gland

N/A

Parathyroid gland

N/A

Adrenal gland

N/A

Bone marrow & immune system

N/A

Appendix

N/A

Bone marrow

N/A

Lymph node

N/A

Tonsil

N/A

Spleen

N/A

Muscle tissues

N/A

Heart muscle

N/A

Skeletal muscle

N/A

Smooth muscle

N/A

Lung

N/A

Nasopharynx

N/A

Bronchus

N/A

Lung

N/A

Liver & gallbladder

N/A

Liver

N/A

Gallbladder

N/A

Pancreas

N/A

Pancreas

N/A

Gastrointestinal tract

N/A

Oral mucosa

N/A

Salivary gland

N/A

Esophagus

N/A

Stomach

N/A

Duodenum

N/A

Small intestine

N/A

Colon

N/A

Rectum

N/A

Kidney & urinary bladder

N/A

Kidney

N/A

Urinary bladder

N/A

Male tissues

N/A

Testis

N/A

Epididymis

N/A

Prostate

N/A

Seminal vesicle

N/A

Female tissues

N/A

Breast

N/A

Vagina

N/A

Cervix, uterine

N/A

Endometrium

N/A

Fallopian tube

N/A

Ovary

N/A

Placenta

N/A

Adipose & soft tissue

N/A

Adipose tissue

N/A

Soft tissue

N/A

Skin

N/A

Skin

N/A

PROTEIN EXPRESSION OVERVIEW
Pending normal tissue annotation.

RNA EXPRESSION OVERVIEW
HPA dataset Organ Expression Alphabetical RNA tissue category: Tissue enriched (epididymis)
GTEx dataset Organ Expression Alphabetical RNA tissue category: Mixed
FANTOM5 dataset Organ Expression Alphabetical RNA tissue category: Tissue enhanced (endometrium, epididymis)

GENE INFORMATION
Gene name	HOXD3 (HGNC Symbol)
Synonyms	HOX1D, HOX4, HOX4A
Description	Homeobox D3 (HGNC Symbol)
Entrez gene summary	This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located at 2q31-2q37 chromosome regions. Deletions that removed the entire HOXD gene cluster or 5' end of this cluster have been associated with severe limb and genital abnormalities. The protein encoded by this gene may play a role in the regulation of cell adhesion processes. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q31.1
Chromosome location (bp)	176136612 - 176173102
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000128652 (version 83.38)
Entrez gene	3232
UniProt	P31249 (UniProt - Evidence at protein level)
neXtProt	NX_P31249
Antibodypedia	HOXD3 antibodies

PROTEIN BROWSER

HOXD3-001	HOXD3-002	HOXD3-004

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
HOXD3-001 ENSP00000249440 ENST00000249440	P31249 [Direct mapping] Homeobox protein Hox-D3 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007160 [cell-matrix adhesion] GO:0007219 [Notch signaling pathway] GO:0009952 [anterior/posterior pattern specification] GO:0010628 [positive regulation of gene expression] GO:0030878 [thyroid gland development] GO:0043565 [sequence-specific DNA binding] GO:0045666 [positive regulation of neuron differentiation] GO:0048704 [embryonic skeletal system morphogenesis] GO:0051216 [cartilage development] Show all	432 aa 45.7 kDa	No	0
HOXD3-002 ENSP00000392615 ENST00000432796	C9J1M3 [Direct mapping] Homeobox protein Hox-D3 Show all	Predicted intracellular proteins Show all	GO:0005654 [nucleoplasm] Show all	100 aa 10.5 kDa	No	0
HOXD3-004 ENSP00000386498 ENST00000410016	P31249 [Direct mapping] Homeobox protein Hox-D3 Show all	Predicted intracellular proteins Transcription factors Helix-turn-helix domains Show all	GO:0003677 [DNA binding] GO:0003700 [transcription factor activity, sequence-specific DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0007160 [cell-matrix adhesion] GO:0007219 [Notch signaling pathway] GO:0009952 [anterior/posterior pattern specification] GO:0010628 [positive regulation of gene expression] GO:0021615 [glossopharyngeal nerve morphogenesis] GO:0030878 [thyroid gland development] GO:0043565 [sequence-specific DNA binding] GO:0045666 [positive regulation of neuron differentiation] GO:0048704 [embryonic skeletal system morphogenesis] GO:0051216 [cartilage development] Show all	432 aa 45.7 kDa	No	0