Expression of PDE11A in cancer - Summary

CANCER ATLAS

Gene description

Phosphodiesterase 11A

Protein class

Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins, Predicted secreted proteins

Protein evidence

Evidence at protein level

Colorectal cancer

Breast cancer

Prostate cancer

Lung cancer

Liver cancer

STAINING SUMMARY

HPA034560

GENE INFORMATION
Gene name	PDE11A
Synonyms
Description	Phosphodiesterase 11A (HGNC Symbol)
Entrez gene summary	The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q31.2
Chromosome location (bp)	177623252 - 178108339
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000128655 (version 83.38)
Entrez gene	50940
UniProt	Q9HCR9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HCR9
Antibodypedia	PDE11A antibodies

PROTEIN BROWSER

PDE11A-001	PDE11A-002	PDE11A-003	PDE11A-004	PDE11A-006	PDE11A-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PDE11A-001 ENSP00000286063 ENST00000286063	Q9HCR9 [Direct mapping] Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A Show all	Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0004112 [cyclic-nucleotide phosphodiesterase activity] GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0004118 [cGMP-stimulated cyclic-nucleotide phosphodiesterase activity] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005829 [cytosol] GO:0006198 [cAMP catabolic process] GO:0007165 [signal transduction] GO:0007596 [blood coagulation] GO:0008081 [phosphoric diester hydrolase activity] GO:0030552 [cAMP binding] GO:0030553 [cGMP binding] GO:0043204 [perikaryon] GO:0046069 [cGMP catabolic process] GO:0046872 [metal ion binding] GO:0047555 [3',5'-cyclic-GMP phosphodiesterase activity] Show all	933 aa 104.8 kDa	No	0
PDE11A-002 ENSP00000351232 ENST00000358450	Q9HCR9 [Direct mapping] Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A Show all	Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0004112 [cyclic-nucleotide phosphodiesterase activity] GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0004118 [cGMP-stimulated cyclic-nucleotide phosphodiesterase activity] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007596 [blood coagulation] GO:0008081 [phosphoric diester hydrolase activity] GO:0030553 [cGMP binding] GO:0046872 [metal ion binding] GO:0047555 [3',5'-cyclic-GMP phosphodiesterase activity] Show all	683 aa 78 kDa	No	0
PDE11A-003 ENSP00000374333 ENST00000389683	Q9HCR9 [Direct mapping] Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A Show all	Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins Predicted intracellular proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0004112 [cyclic-nucleotide phosphodiesterase activity] GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0004118 [cGMP-stimulated cyclic-nucleotide phosphodiesterase activity] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007596 [blood coagulation] GO:0008081 [phosphoric diester hydrolase activity] GO:0030553 [cGMP binding] GO:0046872 [metal ion binding] GO:0047555 [3',5'-cyclic-GMP phosphodiesterase activity] Show all	489 aa 55.7 kDa	No	0
PDE11A-004 ENSP00000386539 ENST00000409504	Q9HCR9 [Direct mapping] Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A Show all	Enzymes ENZYME proteins Hydrolases THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0004112 [cyclic-nucleotide phosphodiesterase activity] GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0004118 [cGMP-stimulated cyclic-nucleotide phosphodiesterase activity] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007596 [blood coagulation] GO:0008081 [phosphoric diester hydrolase activity] GO:0030553 [cGMP binding] GO:0046872 [metal ion binding] GO:0047555 [3',5'-cyclic-GMP phosphodiesterase activity] Show all	575 aa 65.7 kDa	Yes	0
PDE11A-006 ENSP00000416884 ENST00000433879	H7C4D0 [Direct mapping] Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0005515 [protein binding] GO:0007165 [signal transduction] GO:0008081 [phosphoric diester hydrolase activity] GO:0008152 [metabolic process] GO:0046872 [metal ion binding] Show all	437 aa 49.7 kDa	No	0
PDE11A-007 ENSP00000406922 ENST00000436700	H0Y6P9 [Direct mapping] Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A Show all	Predicted intracellular proteins Show all	GO:0004114 [3',5'-cyclic-nucleotide phosphodiesterase activity] GO:0007165 [signal transduction] GO:0008152 [metabolic process] Show all	136 aa 15.5 kDa	No	0