Cell atlas - CHN1 - The Human Protein Atlas

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CHN1

TISSUE

CELL

CANCER

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol

Human cell
	Cytosol

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GENERAL INFORMATION
Gene name	CHN1
Gene description	Chimerin 1
Protein class	Cancer-related genes Disease related genes Plasma proteins Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	9
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the cytosol.
RNA cell category	Cell line enhanced (BJ hTERT+)
Protein evidence	Evidence at protein level
Main location	Localized to the Cytosol (approved)

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA036111
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (BJ hTERT+) Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the cytosol.

Main location

Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA036111	A-431	No staining
	HPA036111	U-2 OS	Cytosol
	HPA036111	U-251 MG	No staining

GENE INFORMATION
Gene name	CHN1 (HGNC Symbol)
Synonyms	ARHGAP2, CHN, DURS2, n-chimerin, RhoGAP2
Description	Chimerin 1 (HGNC Symbol)
Entrez gene summary	This gene encodes GTPase-activating protein for ras-related p21-rac and a phorbol ester receptor. It is predominantly expressed in neurons, and plays an important role in neuronal signal-transduction mechanisms. Mutations in this gene are associated with Duane's retraction syndrome 2 (DURS2). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]
Chromosome	2
Cytoband	q31.1
Chromosome location (bp)	174799363 - 175005369
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000128656 (version 83.38)
Entrez gene	1123
UniProt	P15882 (UniProt - Evidence at protein level)
neXtProt	NX_P15882
Antibodypedia	CHN1 antibodies

PROTEIN BROWSER

CHN1-001	CHN1-002	CHN1-003	CHN1-010	CHN1-011	CHN1-012	CHN1-013	CHN1-014	CHN1-015

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CHN1-001 ENSP00000386741 ENST00000409900	P15882 [Direct mapping] N-chimaerin Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005070 [SH3/SH2 adaptor activity] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0008045 [motor neuron axon guidance] GO:0009967 [positive regulation of signal transduction] GO:0035556 [intracellular signal transduction] GO:0043087 [regulation of GTPase activity] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] GO:0046875 [ephrin receptor binding] GO:0048013 [ephrin receptor signaling pathway] GO:0050770 [regulation of axonogenesis] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	459 aa 53.2 kDa	No	0
CHN1-002 ENSP00000295497 ENST00000295497	P15882 [Direct mapping] N-chimaerin Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005070 [SH3/SH2 adaptor activity] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0008045 [motor neuron axon guidance] GO:0009967 [positive regulation of signal transduction] GO:0035556 [intracellular signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] GO:0048013 [ephrin receptor signaling pathway] GO:0050770 [regulation of axonogenesis] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	334 aa 38.2 kDa	No	0
CHN1-003 ENSP00000386470 ENST00000409156	P15882 [Direct mapping] N-chimaerin Show all	Predicted intracellular proteins Plasma proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005070 [SH3/SH2 adaptor activity] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005829 [cytosol] GO:0007165 [signal transduction] GO:0007264 [small GTPase mediated signal transduction] GO:0008045 [motor neuron axon guidance] GO:0009967 [positive regulation of signal transduction] GO:0035556 [intracellular signal transduction] GO:0043547 [positive regulation of GTPase activity] GO:0046872 [metal ion binding] GO:0048013 [ephrin receptor signaling pathway] GO:0050770 [regulation of axonogenesis] GO:0051056 [regulation of small GTPase mediated signal transduction] Show all	433 aa 50 kDa	No	0
CHN1-010 ENSP00000409798 ENST00000443238	C9JR98 [Direct mapping] N-chimaerin Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0007165 [signal transduction] GO:0035556 [intracellular signal transduction] GO:0046872 [metal ion binding] Show all	186 aa 21.4 kDa	No	0
CHN1-011 ENSP00000411911 ENST00000444394	C9J3G1 [Direct mapping] N-chimaerin Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0007165 [signal transduction] GO:0035556 [intracellular signal transduction] Show all	173 aa 19.7 kDa	No	0
CHN1-012 ENSP00000386322 ENST00000409089	F8W6K2 [Direct mapping] N-chimaerin Show all	Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0007165 [signal transduction] Show all	194 aa 21.8 kDa	No	0
CHN1-013 ENSP00000410496 ENST00000413882	C9J3V9 [Direct mapping] N-chimaerin Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0007165 [signal transduction] GO:0035556 [intracellular signal transduction] GO:0046872 [metal ion binding] Show all	185 aa 20.9 kDa	Yes	0
CHN1-014 ENSP00000386469 ENST00000409597	B8ZZ96 [Direct mapping] N-chimaerin Show all	THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0007165 [signal transduction] GO:0035556 [intracellular signal transduction] GO:0046872 [metal ion binding] Show all	275 aa 31.3 kDa	Yes	0
CHN1-015 ENSP00000392603 ENST00000444573	C9J1N1 [Direct mapping] N-chimaerin Show all	SCAMPI predicted membrane proteins Predicted intracellular proteins Cancer-related genes COSMIC somatic mutations in cancer genes COSMIC Somatic Mutations COSMIC Translocations Protein evidence (Ezkurdia et al 2014) Show all	GO:0005622 [intracellular] GO:0035556 [intracellular signal transduction] GO:0046872 [metal ion binding] Show all	165 aa 18.6 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.